Just two of the original C50 class Winterthur and Hartmann Pacifics built just prior to the First World War now survive in South Sumatra. These locomotives are now to be found at Tandjungkarang pulling local trains, this is C5005. These 1912 C51 Beyer Peacock 4-6-0 have been modified ex works with smoke deflectors.

PNKA steam locomotives. All dimensions metric: lengths in mm, areas in m 2, weights in metric tons, pressures in atmospheres.

On another tour organized by David Thornhill of World Steam, I was able to visit Java, Malaysia and Singapore in 1973, when there were some incredibly ancient steam locomotives still in use as well as more modern traction. As with many places, the history of Indonesian Railways is pretty complicated, suffice to say tha…

近日，奥地利科学院孟德尔研究所 (The Gregor Mendel Institute, GMI) 的Yasin Dagdas团队以及其合作者在 eLife 杂志在线发表题为 A cross-kingdom conserved ER-phagy receptor maintains endoplasmic reticulum homeostasis during stress 的研究论文。 该研究筛选到动植物中非常保守的内质网受体蛋白C53，并对其参与的内质网自噬降解途径以及调控胁迫过程的分子机制进行了深入解析。 该研究中，作者用创新的peptide competition偶联的蛋白质组亲和筛选系统，筛选了植 …

On another tour organized by David Thornhill of World Steam, I was able to visit Java, Malaysia and Singapore in 1973, when there were some incredibly ancient steam locomotives still in use as well as more modern traction. As with many places, the history of Indonesian Railways is pretty complicated, suffice to say tha…

为了增加可用于成像的活化STING的数量，这些作者加入了一种称为化合物53（C53）的研究性药物，它目前正作为STING激活剂进行抗癌治疗的测试。 C53被认为与cGAMP结合在STING上的同一位点。 cGAMP和C53的组合使用产生了明显更多的活化STING分子。 但是当这些作者在低温电镜图片上寻找C53时，他们发现它的结合位置与cGAMP完全不同，在STING分子的另一端。 Bai解释说，“这个新发现的活化STING的结合位点完全出乎意料。 我们称它为‘隐性口袋（cryptic …

2023年8月9日 · 该研究揭示了人体STING蛋白的一项新功能，即作为氢离子通道介导Golgi内氢离子的外流，从而导致细胞内pH值上升。 这一过程进而参与了非经典自噬的调节以及NLRP3炎症小体的激活机制。 在深入研读多领域文献后，研究团队发现STING引发的两条独立下游通路（非经典自噬和NLRP3炎症小体的激活）与Golgi/endosome氢离子外流密切相关。 基于这一观察，他们提出了一个假设，即STING可能通过诱发氢离子外流来激活这两条下游通路。 利用针对Golgi特 …

2023年5月31日 · Realme C53 Android smartphone. Announced May 2023. Features 6.74″ display, Unisoc Tiger T612 chipset, 5000 mAh battery, 256 GB storage, 8 GB RAM.

Here we established that C53 selectively generates cGMP via the pGC-B receptor and is highly resistant to NEP and has less interaction with NPRC in vitro. Furthermore in vivo, C53 had enhanced cGMP-generating actions that paralleled elevated plasma CNP-like levels, thus indicating a longer circulating half-life compared to CNP.

C53 senses ER stress by forming a tripartite receptor complex that involves UFL1, the E3 ligase that mediates ufmylation, and its ER-resident adaptor protein DDRGK1. C53 activity is regulated by another ubiquitin-like protein, UFM1, which is transferred from C53 to the ribosomes upon ribosome collision/stalling at the ER, thereby activating the ...