2025年1月5日 · 骨髓间充质干细胞（BMSCs）是一种多能干细胞，因其在改善卵巢功能和恢复POI女性生育能力方面的重要作用而受到越来越多的关注。 本研究旨在评估BHR对POI小鼠的治疗效果，并探讨其潜在机制。 通过单次腹腔注射120mg/kg环磷酰胺（CTX）建立POI小鼠模型。 连续28天通过强饲法给予蒸馏水、BHR或脱氢表雄酮。 通过评估动情周期、卵巢形态、卵泡发育、激素水平和血管生成，评估BHR对POI小鼠卵巢功能的影响。 通过流式细胞术分析骨髓、外周 …

2024年4月24日 · Bone marrow mesenchymal stem cells (BMSCs), a type of pluripotent stem cells, have received increasing attention for their significant role in improving ovarian function and restoring fertility in women with POI. This study aimed to evaluate the therapeutic effect of BHR in POI mice and explore its potential mechanism.

2024年2月22日 · Igboeli等人记录了两名患有POF的白人患者，在腹腔镜自体BMSC移植到卵巢后， 她们表现出卵巢激素分泌恢复、月经周期改善、更年期症状减轻 。临床研究也为POF患者进行BMSC移植以实现成功妊娠的效用提供了有希望的证据。

2023年7月1日 · BMSC-secretomes protected myofibers against tissue injury and apoptosis by boosting the expression of pro-survival AKT molecules and lowering the expression of cytochrome-c, activated-caspase-3, and other pro-apoptotic indicators [71].

2024年6月1日 · Taken together, the results of this study highlight the potential of BMSC-Exo as a vehicle to transport miR-21 into the ovary and demonstrate the anti-apoptotic role of miR-21 in autoimmune POI by inhibiting MSX1. Importantly, this study demonstrated that miR-21-loaded BMSC-derived Exo regulated the MSX1-mediated Notch pathway to inhibit ...

2024年7月1日 · Bone marrow mesenchymal stem cells (BMSCs), a type of pluripotent stem cells, have received increasing attention for their significant role in improving ovarian function and restoring fertility in women with POI. This study aimed to evaluate the therapeutic effect of BHR in POI mice and explore its potential mechanism.

2025年2月5日 · 早发性卵巢功能不全（poi），亦称卵巢早衰，指的是40岁之前女性卵巢功能的衰退。据一项荟萃分析推算，全球约有3.5%的女性受到poi的影响。该状况可能导致不孕、泌尿生殖系统萎缩以及骨质疏松，并可能提升心血管疾病与神经退行性疾病的风险。因此，它对 ...

2021年2月25日 · Our findings indicate that the hMSC secretome may be a novel treatment approach for restoring granulosa cell and ovarian function in patients with POI. Primary ovarian insufficiency (POI) is defined as the loss of ovarian function before 40 years of age. It clinically manifests as amenorrhea, infertility, and signs of estrogen insufficiency.

2024年4月29日 · 这项研究旨在评估BHR在POI小鼠中的治疗效果，并探索其潜在机制。研究建立了POI小鼠模型，通过腹腔单次注射120 mg/kg环磷酰胺（CTX）进行。连续28天通过灌胃给予蒸馏水、BHR或去氢表雄酮。

This research investigates how miR-21-Exo influences chemotherapy-induced POI using an experimental model where KGN cells are exposed to cisplatin. We assessed the impact of miR-21 on cellular activity and generated miR-21 overexpressing bone marrow mesenchymal stem cells (miR-21-BMSC) via lentiviral modification.