2024年12月25日 · POLR3C (RNA Polymerase III Subunit C) is a Protein Coding gene. Diseases associated with POLR3C include Primary Immunodeficiency With Predisposition To Severe Viral Infection and Wiedemann-Rautenstrauch Syndrome. Among its related pathways are RNA Polymerase III Transcription Initiation and Innate Immune System.

Enables single-stranded DNA binding activity. Involved in positive regulation of innate immune response and positive regulation of interferon-beta production. Located in nucleoplasm. Part of RNA polymerase III complex. [provided by Alliance of Genome Resources, Apr 2022]

DNA-directed RNA polymerase III subunit RPC3 is an enzyme that in humans is encoded by the POLR3C gene. [5] [6] [7]

Gene ID: 10623, updated on 8-Feb-2025. Enables single-stranded DNA binding activity. Involved in positive regulation of innate immune response and positive regulation of interferon-beta production. Located in nucleoplasm. Part of RNA polymerase III complex. [provided by Alliance of Genome Resources, Feb 2025]

POLR3-related or 4H (hypomyelination, hypodontia, and hypogonadotropic hypogonadism) leukodystrophy is one of the most common types of hypomyelinating leukodystrophy for which no curative treatment or disease-modifying therapy is available.

RNA polymerase III (Pol III) contains at least 16 subunits and transcribes genes that produce small structural RNAs, like tRNAs. POLR3C encodes a subunit of a Pol III subcomplex required for specific promoter-directed transcription initiation by the holoenzyme (Wang and Roeder, 1997).

具有单链dna结合活性。参与天然免疫反应的正调控和干扰素-β产生的正调控。位于核质中。是rna聚合酶iii复合物的一部分。[由基因组资源联盟，2022年4月提供]

Gene ID: 74414, updated on 8-Feb-2025. Predicted to enable single-stranded DNA binding activity. Predicted to be involved in positive regulation of innate immune response and positive regulation of interferon-beta production. Predicted to be located in nucleoplasm. Predicted to be part of RNA polymerase III complex.

Predicted to enable single-stranded DNA binding activity. Predicted to be involved in positive regulation of innate immune response and positive regulation of interferon-beta production. Predicted to be located in nucleoplasm. Predicted to be part of RNA polymerase III complex. Orthologous to human POLR3C (RNA polymerase III subunit C).

Predicted to be involved in positive regulation of innate immune response and positive regulation of interferon-beta production. Predicted to be located in nucleoplasm. Predicted to be part of RNA polymerase III complex.