Poly ICLC is an immunostimulant. It is polyinosinic-polycytidylic acid (poly I:C) mixed with the stabilizers carboxymethylcellulose and polylysine. [1] It is under trial for use in cancer. [2] Poly I:C is a ligand for toll like receptor-3, which usually triggers on the structurally similar double-stranded RNA present in some viruses. [1]

添加第二种成分poly-ICLC（一种激活树突状细胞的TLR3激动剂），也增强了树突状细胞促进抗体以及辅助性和杀伤性T细胞的能力。 研究小组说，结果很重要，因为大多数癌症疫苗试验都未能显示出临床疗效。

We emphasize the role of poly-ICLC as an adjuvant in the setting of peptide-based cancer vaccines and in situ tumor vaccination by mimicking natural immune responses to infections. Finally, we summarize the impact of poly-ICLC in enhancing T infiltration into the tumor parenchyma and address the implication of this finding in the clinic.

Polyinosinic-polycytidylic acid (Poly(I:C)) 是双链 RNA 的合成类似物，是一种 TLR3 和视黄酸诱导型基因 I 受体 (RIG-I 和 MDA5) 的激动剂。 Polyinosinic-polycytidylic acid 可以用作疫苗佐剂，以增强先天性和适应性免疫反应，并改变肿瘤的微环境，还可以直接触发癌细胞发生凋亡 ...

2020年6月1日 · Poly-ICLC is a strong adjuvant for peptide cancer vaccines promoting the expansion of T cells. Systemic poly-ICLC enhances T cell infiltration through MDA5 stimulation and IFN-I production. Clinically, poly-ICLC induces in …

2021年6月25日 · Here, we present a systematic review on the effects and efficacy of poly(I:C)/poly-ICLC for glioblastoma treatment, ranging from preclinical work on cellular and murine glioblastoma models to reported and ongoing clinical studies.

2024年11月13日 · Cotreatment with poly-ICLC significantly enhanced the antitumor effects of anti-PD-1, with IT administration being more effective than IM. IT poly-ICLC also induced more significant CD8 + T cell infiltration and interferon-γ activity in the tumor and spleen, and more upregulation of both interferon-γ and M1 macrophage signals in the tumor ...

Poly-ICLC is a cancer vaccine (immunotherapy) made from RNA, which may help the body build an effective immune response to kill tumor cells. Injecting the vaccine directly into the tumor may cause a stronger immune response and kill more tumor cells.

poly-ICLC是一种合成的双链RNA复合物，toll样受体-3和MDA-5的配体，可激活免疫细胞（如树突状细胞），并诱导自然杀伤细胞杀死肿瘤细胞。 CLIN CANCER RES近期发表了一篇文章，研究poly-ICLC治疗实体瘤的效果。

2021年6月25日 · Here, we present a systematic review on the effects and efficacy of poly(I:C)/poly-ICLC for glioblastoma treatment, ranging from preclinical work on cellular and murine glioblastoma models to reported and ongoing clinical studies.