The polyol pathway is a two-step process that converts glucose to fructose. [1] In this pathway glucose is reduced to sorbitol, which is subsequently oxidized to fructose. It is also called the sorbitol-aldose reductase pathway .

2005年6月1日 · Finally, inhibition of GAPDH increases intracellular levels of the first glycolytic metabolite, glucose. This increases flux through the polyol pathway, where the enzyme aldose reductase reduces it, consuming NADPH in the process.

The polyol pathway is a metabolic route that converts glucose into fructose through the intermediate sorbitol, involving two key enzymes: aldose reductase and sorbitol dehydrogenase. This pathway plays a significant role in cellular biochemistry and energy metabolism, particularly under hyperglycemic conditions, as it contributes to the ...

2022年6月10日 · The polyol pathway is a two-step metabolic pathway, in which glucose is reduced to sorbitol then converted to fructose . Although physiological functions of this pathway remain elusive, the genes encoding polyol pathway enzymes are conserved from yeasts to humans, suggesting that it plays an important as yet unknown role across species.

When glucose is unused, it is metabolized via the polyol pathway. This pathway consists of two main enzymatic steps. First, glucose is reduced to sorbitol by aldose reductase. In this step, NADPH is oxidized to NADP+. The next step is the oxidation of sorbitol to D-fructose by sorbitol dehydrogenase.

The polyol pathway is a two-step metabolic pathway in which glucose is reduced to sorbitol, which is then converted to fructose. Several biochemical features and a large body of data implicate the polyol pathway as a plausible and important contributor to diabetic...

2021年6月28日 · The polyol pathway is a biological process wherein glucose is converted into fructose. It is called polyol because glucose is first reduced to a polyol sorbitol. Sorbitol is then oxidized to fructose.

2023年6月12日 · The biosynthesis of sorbitol occurs through the polyol pathway, while its degradation primarily happens through the sorbitol dehydrogenase pathway. Understanding the factors influencing sorbitol degradation kinetics is essential for optimizing enzymatic reactions and industrial processes.

When glucose is unused, it is metabolized via the polyol pathway. This pathway consists of two main enzymatic steps. First, glucose is reduced to sorbitol by aldose reductase. In this step, NADPH is oxidized to NADP+. The next step is the oxidation of sorbitol to D-fructose by sorbitol dehydrogenase.

2023年4月5日 · The polyol pathway converts excess glucose into sorbitol and fructose. In diabetic conditions, the polyol pathway is activated and accelerates diabetic microvascular complications such as diabetic neuropathy [93,94,95].