2007年1月1日 · In the nematode Caenorhabditis elegans, Wnt signaling controls developmental processes such as cell fate specification, cell migration, and cell polarity. C. elegans utilizes conserved Wnt/β‐catenin as well as novel signaling pathways to mediate Wnt signaling.

In the embryo, a novel Wnt pathway functions through a (beta)-catenin homolog, WRM-1, to downregulate the levels of POP-1/Tcf in the posterior daughter of the EMS blastomere. The level of POP-1 is also lower in the posterior daughters of many anteroposterior asymmetric cell divisions during development.

2005年9月15日 · Contrary to this model, we demonstrate here that POP-1 directly activates Wnt target genes in the endoderm precursor. Wnt converts POP-1 from a repressor to an activator, and this conversion requires that POP-1 nuclear levels be lowered in the endoderm precursor.

2001年2月15日 · In Caenorhabditis elegans, Wnt signaling pathways are important in controlling cell polarity and cell migrations. In the embryo, a novel Wnt pathway functions through a β-catenin homolog, WRM-1, to downregulate the levels of POP-1/Tcf in …

2005年9月15日 · Wnt converts POP-1 from a repressor to an activator, and this conversion requires that POP-1 nuclear levels be lowered in the endoderm precursor. We propose that the balance between TCF/LEF and coactivator(s), achieved by elevating coactivator levels (the canonical pathway) and/or reducing TCF/LEF levels (worm endoderm), determines Wnt signal ...

2010年4月15日 · The nuclear Wnt effector TCF/POP-1 plays a central role in specification of MS. Loss of maternal pop-1 function through the maternal-specific allele zu189 or by RNAi results in a penetrant mis-specification of MS as an E-like precursor (Lin et al., 1998, Lin et al., 1995).

We identify three lysines that are acetylated in vivo, and demonstrate their essential requirement for proper nuclear localization and biological activity of POP-1 during C. elegans embryogenesis.

2010年4月15日 · Our results suggest that POP-1 is not critical for MS specification beyond repression of endoderm specification, and reveal that Wnt-modified POP-1 and END-1/3 further reinforce E specification by repressing MS fate in E.

2001年2月28日 · In Caenorhabditis elegans, Wnt signaling pathways are important in controlling cell polarity and cell migrations. In the embryo, a novel Wnt pathway functions through a (beta)-catenin homolog,...

2007年12月31日 · We report that Wnt and Frizzled homologs that activate Ca2+ release and PKC also activate CamKII activity in Xenopus embryos, while Wnt and Frizzled homologs that activate β-catenin function do...