Peste des petits ruminants (PPR) is an acute transboundary infectious viral disease affecting domestic and wild small ruminants' species besides camels reared in Africa, Asia and the Middle East. The virus is a serious paramount challenge to the sustainable agriculture advancement in the developing world.

2016年8月13日 · PPRV antigen and nucleic acid detection techniques can be used when sampling is performed during active outbreaks of disease, i.e., for diagnosis or clinical surveillance. However, many of these PPRV antigen and nucleic acid detection techniques can only be applied between 4 and 17 days postinfection.

2019年12月1日 · PPR eradication is launched by worldwide organizations by 2030. Current and prospective strategies for PPR eradication. Proper use of diagnostic tools supports PPR diagnosis and eradication. Opinion for better improvement of the current attenuated vaccines. Novel PPR vaccines and PPR eradication.

2020年1月29日 · The development of necessary tools for PPRV control, including vaccines and diagnostics, greatly relied on detailed insights into the PPRV genome and protein constituents; and on this same basis the virus is now classified into lineages.

This study focused mainly on the production of a peptide vaccine against H, M, F, and N proteins of PPRV using immunoinformatics tools. Epitopes that showed conservancy and high binding affinities to many MHC alleles are considered the best candidates for in vitro and in vivo testing.

The idea behind the “ FastCheck FLI PPR-like” was to develop a diagnostic tool that focuses on fast and flexible PPRV diagnostics integrating the detection of additional pathogens, since the clinical similar signs of that pathogens complicate reliable diagnostics in the field. The different components are designed as a modular nucleic acid ...

Commercially available rapid detection methods for PPRV antigen (two Lateral Flow Devices (LFD) and one antigen ELISA) were evaluated in comparison with a nucleic acid detection method. For this...

2019年3月18日 · Non-invasive strategies to detect PPR infection without the need for animal handling could greatly facilitate research on PPR epidemiology and management of the disease in atypical hosts and in...

2013年11月27日 · Peste des petits ruminants (PPR) is an acute, highly contagious, world organization for animal health (OIE) notifiable and economically important transboundary viral disease of sheep and goats associated with high morbidity …

2016年11月1日 · This article provides an overview of the various PPR diagnostic tools and suggests where and how they should be logically applied during the different phases of global PPR control and eradication.