2024年12月25日 · PRKCQ (Protein Kinase C Theta) is a Protein Coding gene. Diseases associated with PRKCQ include Inflammatory Bowel Disease 1 and Amelogenesis Imperfecta, Type Iiia. Among its related pathways are Prolactin Signaling and ADORA2B mediated anti-inflammatory cytokines production.

Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by the second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways.

PRKCQ is the only T cell-expressed protein kinase C that localizes selectively to center of immunological synapse following T cell antigen stimulation; this unique localization is essential for PRKCQ-mediated downstream signaling.

蛋白激酶 Cθ： 蛋白激酶 C (PKC) 是一个丝氨酸和苏氨酸特异性蛋白激酶家族，可被钙和第二信使甘油二酯激活。 PKC 家族成员磷酸化多种蛋白质靶标，并且已知参与多种细胞信号通路。 PKC 家族成员还充当佛波酯 (一类肿瘤促进剂) 的主要受体。 PKC 家族的每个成员都有特定的表达谱，并 …

Enables protein kinase C activity. Involved in several processes, including positive regulation of NF-kappaB transcription factor activity; positive regulation of cytokine production; and regulation of cell-cell adhesion.

2025年1月4日 · Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and the second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways.

2025年2月8日 · protein kinase C theta type, PKC theta, nPKC-theta. Distinct subcellular localisation of intramyocellular lipids and reduced PKCepsilon/PKCtheta; activity preserve muscle insulin sensitivity in exercise-trained mice. Protein kinase C-theta knockout decreases serum IL-10 levels and inhibits insulin secretion from islet beta cells.

Protein tyrosine kinase C theta isoform (PRKCQ) overexpression promotes multiple oncogenic activities in breast epithelial cells. a Non-transformed, immortalized MCF-10A cells overexpressing vector control or PRKCQ were generated, and assessed for their ability to survive in suspension cultures using the Cell Death ELISA assay.

蛋白激酶C（PKC）是一类特异性的丝氨酸和苏氨酸蛋白激酶家族，可以通过钙离子和第二信使二酯酰甘油激活。 PKC家族成员可以磷酸化各种蛋白质靶标，并已知参与多种细胞信号传导途径。 PKC家族成员还作为佛波酯类的一类肿瘤促进剂的主要受体。 PKC家族每个成员都有特定的表达模式，并被认为扮演独特的角色。 这个基因编码的蛋白质是PKC家族成员之一。 它是一种不依赖于钙离子且依赖于磷脂的蛋白激酶。 这种激酶对于T细胞的激活是必要的。 它对于转录因子NF …

2010年5月10日 · HGNC Approved Gene Symbol: PRKCQ. Cytogenetic location: 10p15.1 Genomic coordinates (GRCh38) : 10:6,394,097-6,580,646 (from NCBI) Members of the protein kinase C (PKC) family of serine/threonine kinases play critical roles in the regulation of cellular differentiation and proliferation of diverse cell types.