Pro-IGF-2 and IGF-2 suppress both insulin and growth hormone (GH), which in turn decreases the production of IGF-1 and IGFBP-3, the principal binding protein for IGF-2. Furthermore, pro-IGF-2 inherently binds to IGFBP-3 poorly, thereby further increasing the availability of pro-IGF-2 to stimulate insulin receptors and glucose uptake.

2023年8月19日 · Here, we found that pro-IGF2(156) has the lowest ability to form its inactivating complexes with IGF-Binding Proteins and has higher proliferative properties in cells than IGF2 and other IGF...

2013年12月1日 · In a minority of patients, the tumors (hepatomas, fibromas, and fibrosarcomas are the most common among many) release into the circulation enough IGF-2–related peptides to mimic the fasting hypoglycemia characteristic of patients with insulin-producing islet-cell tumors.

Insulin-like growth factor-II (IGF-II) is a widely expressed 7·5 kDa mitogenic peptide hormone. Although it is abundant in serum, understanding of its physiological role is limited compared with that of IGF-I. IGF-II regulates foetal development and differentiation, but its role in adults is less well understood.

2024年12月25日 · IGF2 (Insulin Like Growth Factor 2) is a Protein Coding gene. Diseases associated with IGF2 include Silver-Russell Syndrome 3 and Silver-Russell Syndrome 1. Among its related pathways are Apoptotic Pathways in Synovial Fibroblasts and GPCR Pathway.

We provide a detailed description of Igf2 mRNA expression regulation and pre-pro-IGF-2 protein processing in different species. We also summarize the function of IGF-binding proteins. We describe three different receptors able to bind IGF-2 and discuss the role of IGF-2 signaling in learning and memory, as well as in neuroprotection.

2017年5月16日 · Here, we present a patient with advanced-stage HCC, presenting with severe hypoinsulinaemic hypoglycaemia due to increased tumour-mediated IGF-2 synthesis. The increased bioavailability of IGF-2 and Pro-IGF2 has pleotropic effects on glucose metabolism mediated through the insulin–IGF-1 family of receptors, causing hypoglycaemia ( 5 ).

1998年7月17日 · As a first step toward understanding how high molecular weight IGF-2 peptides might contribute to tumor progression, we have characterized the biosynthesis of IGF-2 in a human embryonic cell line. We have found that pro-IGF-2 can initially form two disulfide isomers that undergo rearrangement to a single conformation in vivo.

2023年8月19日 · Insulin-like Growth Factor-2 (IGF2) is important for the regulation of human embryonic growth and development, and for adults’ physiology. Incorrect processing of the IGF2 precursor, pro-IGF2 (156), leads to the formation of two IGF2 proforms, big …

2005年8月2日 · Insulin-like growth factor II (IGF-II) has been shown to be an important regulator of fetoplacental growth. This growth factor must undergo posttranslational processing, and, thus, we hypothesized that aberrant processing of pro-IGF-II to IGF-II may be a cause of IUGR.