A Unique Case of IGF-2 Induced Hypoglycemia Associated with ...
Pro-IGF-2 and IGF-2 suppress both insulin and growth hormone (GH), which in turn decreases the production of IGF-1 and IGFBP-3, the principal binding protein for IGF-2. Furthermore, pro …
Non-glycosylated IGF2 prohormones are more mitogenic than
2023年8月19日 · Here, we found that pro-IGF2(156) has the lowest ability to form its inactivating complexes with IGF-Binding Proteins and has higher proliferative properties in cells than IGF2 …
Tumors, IGF-2, and Hypoglycemia: Insights From the Clinic, the ...
2013年12月1日 · In a minority of patients, the tumors (hepatomas, fibromas, and fibrosarcomas are the most common among many) release into the circulation enough IGF-2–related …
Insulin‐like growth factor‐II: its role in metabolic and endocrine ...
Insulin-like growth factor-II (IGF-II) is a widely expressed 7·5 kDa mitogenic peptide hormone. Although it is abundant in serum, understanding of its physiological role is limited compared …
IGF2 Gene - GeneCards | IGF2 Protein | IGF2 Antibody
2024年12月25日 · IGF2 (Insulin Like Growth Factor 2) is a Protein Coding gene. Diseases associated with IGF2 include Silver-Russell Syndrome 3 and Silver-Russell Syndrome 1. …
Insulin-Like Growth Factor 2 As a Possible Neuroprotective Agent …
We provide a detailed description of Igf2 mRNA expression regulation and pre-pro-IGF-2 protein processing in different species. We also summarize the function of IGF-binding proteins. We …
Pro-IGF2-induced hypoglycaemia associated with hepatocellular …
2017年5月16日 · Here, we present a patient with advanced-stage HCC, presenting with severe hypoinsulinaemic hypoglycaemia due to increased tumour-mediated IGF-2 synthesis. The …
Post-translational processing of the insulin-like growth factor-2 ...
1998年7月17日 · As a first step toward understanding how high molecular weight IGF-2 peptides might contribute to tumor progression, we have characterized the biosynthesis of IGF-2 in a …
Non-glycosylated IGF2 prohormones are more mitogenic than …
2023年8月19日 · Insulin-like Growth Factor-2 (IGF2) is important for the regulation of human embryonic growth and development, and for adults’ physiology. Incorrect processing of the …
Role of pro-IGF-II processing by proprotein convertase 4 in …
2005年8月2日 · Insulin-like growth factor II (IGF-II) has been shown to be an important regulator of fetoplacental growth. This growth factor must undergo posttranslational processing, and, …