Progastrin is an 80-amino acid intracellular protein and the precursor of gastrin, a gastrointestinal hormone produced by G cells in the gastric antrum. [1] The main function of gastrin is to regulate acid secretion. [ 2 ]

It has been shown recently that the two largest alpha-carboxyamidated progastrin products are gastrin-71 and gastrin-52. Human gastrin-52 has now been synthesized, and the effect on gastric acid secretion and elimination from plasma was examined and compared with gastrin-17 in 12 normal subjects.

In humans, progastrin is processed to six bioactive gastrin's (gastrin -71, -52, -34, -17, -14, and -6) of which the five longest circulate in both a tyrosyl O-sulfated and a non-sulfated form (Fig. 2) [for reviews, see refs.

Progastrin is a precursor molecule of gastrin, synthesized as pre-progastrin, converted to progastrin after cleavage, and transformed into amidated gastrin via biosynthetic intermediates. In cancer, progastrin does not maturate in gastrin and becomes a …

2012年12月7日 · Progastrin may exert greater proliferative effects than amidated gastrins on normal and tumor cells (CRC, pancreatic) in culture[28,86] and also has an antiapoptotic effect. In vivo studies using mice overexpressing both G17-NH 2 and PG showed increased colonic proliferation compared to wild-type control mice.

Secretion of progastrin is a signature event of early malignant transformation in the colon. In the healthy epithelium, progastrin is produced by a subset of enteroendocrine cells expressing both Bmi1 and Prox1. LGR5-high intestinal stem cells are a primary source of progastrin production in early mouse and human intestinal adenomas.

ProGRP偏高一般指检测结果大于50pg/mL，可能由于样本污染、操作失误所致，也可提示小细胞肺癌、甲状腺髓样癌等恶性肿瘤，以及泌尿系统、呼吸系统等良性疾病。 样本污染、操作失误等原因，可能导致ProGRP假性偏高。 小细胞肺癌，ProGRP常常升高到十几倍甚至几十倍。 其他神经内分泌细胞肿瘤，如甲状腺髓样癌，ProGRP也可能有一定程度地偏高。 泌尿系统、呼吸系统疾病，如肾功能衰竭、肾炎、肺炎等，ProGRP也可能有轻度偏高。 ProGRP偏高本身不会对身体 …

In this study, we examined the effects of N‐terminal progastrin fragments on gastric acid secretion by infusion in healthy individuals. Increasing doses of progastrin fragment 1‐35 were infused intravenously during constant gastric acid stimulation by gastrin‐17.

The kinetics and metabolism in various organs of three bioactive products of progastrin, the small sulfated and nonsulfated gastrin-6 and the large nonsulfated gastrin-52, were examined during intravenous administration in anesthetized pigs. The kidney, hindlimb, liver, head, and gut eliminated the …

Progastrin is the precursor of the gastrointestinal hormone, gastrin, which regulates gastric mucosal growth and gastric acid secretion. As indicated in Figures 1 and 2 , the maturation of progastrin in the antroduodenal G-cells is complex and requires multiple enzymatic processes.