PROTAC技术 - 知乎 - 知乎专栏
PROTAC（proteolysis-targeting chimeras）是一种利用 泛素－蛋白酶体系统 （Ubiquitin-Proteasome System, UPS）对靶蛋白进行降解的药物开发技术。 在结构上，PROTAC包括三 …
Proteolysis targeting chimera - Wikipedia
A heterobifunctional molecule with two active domains and a linker, PROTACs consist of two covalently linked protein-binding molecules: one capable of engaging an E3 ubiquitin ligase, …
PROTACs：学术界和产业界的巨大机遇 - 知乎 - 知乎专栏
蛋白水解靶向嵌合体 （PROteolysis TArgeting Chimeras，PROTACs）已成为一种有前途的通过降解调控兴趣蛋白(protein ofinterest，POI)的技术。 一、原理. 像哑铃一样的PROTACs技 …
An overview of PROTACs: a promising drug discovery paradigm
2022年12月22日 · Proteolysis targeting chimeras (PROTACs) technology has emerged as a novel therapeutic paradigm in recent years. PROTACs are heterobifunctional molecules that …
PROTACs: great opportunities for academia and industry
2019年12月24日 · PROTACs regulate protein function by degrading target proteins instead of inhibiting them, providing more sensitivity to drug-resistant targets and a greater chance to …
PROTACs: past, present and future - PubMed
2022年6月20日 · Proteolysis-targeting chimeras (PROTACs) are heterobifunctional molecules consisting of one ligand that binds to a protein of interest (POI) and another that can recruit an …
PROTAC targeted protein degraders: the past is prologue
2022年1月18日 · With clinical proof-of-concept for PROTAC molecules against two well-established cancer targets provided in 2020, the field is poised to pursue targets that were …
PROTAC最新综述：聚焦抗癌 - 知乎 - 知乎专栏
PROTACs全称为Proteolysis-Targeting Chimeras，即蛋白水解靶向嵌合体，其结构看起来像哑铃一样，通过一个“连接器“（linker）连接“兴趣蛋白的配体”以及“E3泛素连接酶的招募配体”。
珍藏版：PROTAC技术详细梳理|蛋白酶体|蛋白质|降解|药物|-健康界
2021年1月24日 · protacs技术就是利用这种降解机制，使得靶蛋白以蛋白酶体依赖的方式不可逆地被移除，从而治疗疾病，由此可见这其实是一种与传统小分子抑制剂甚至抗体截然不同的作用 …
PROTACs: An Emerging Targeting Technique for Protein
Proteolysis-targeting chimeric molecules (PROTACs) represent an emerging technique that is receiving much attention for therapeutic intervention. The mechanism is based on the …