Prospero homeobox protein 1 is a protein that in humans is encoded by the PROX1 gene. [5] [6] The Prox1 gene is critical for the development of multiple tissues. Prox1 activity is necessary …

2024年12月25日 · PROX1 (Prospero Homeobox 1) is a Protein Coding gene. Diseases associated with PROX1 include Lymphangioma and Generalized Lymphatic Anomaly. Among …

2025年2月13日 · We validated hepatocyte-specific candidates using reprogramming, revealing that prospero homeobox protein 1 (PROX1) enhanced hepatocyte identity by direct repression …

2022年11月24日 · Here, we identify Prospero-related homeobox 1 (PROX1) as a crucial factor for tumour metabolic plasticity. Notably, PROX1 is reduced by glucose starvation or AMP …

2025年2月17日 · 这项研究颠覆了传统认知——过去认为细胞身份主要依赖激活自身基因，而prox1机制证明持续压制"异心基因"同等重要。当研究人员在小鼠中敲除prox1，62%的肝细胞 …

2018年6月22日 · Here, we show that PROX1 suppresses the transcription of MMP14, a metalloprotease involved in angiogenesis and cancer invasion, by binding and suppressing …

2024年8月10日 · In this study, we identified PROX1 as a driver of neuroendocrine plasticity in PCa, responsible for promoting liver metastases. Mechanistically, anti-androgen therapy …

2023年6月27日 · Here, we show that enhanced autolysosomal activity mediated by mTORC1 inhibition induces PROX1 expression and that PROX1 induction in turn inhibits NOX1 …

该基因编码的蛋白质是同源框转录因子家族的成员。 该家族的成员包含一个同源框结构域，该结构域由结合 DNA 和 RNA 的 60 个氨基酸的螺旋-转角-螺旋结构组成。 由该基因编码的蛋白质在 …

摘要：同源异型蛋白Prox1 (Prospero homeobox1)是果蝇Prospero蛋白在脊椎动物中的同源物，它在眼球、视网膜、肝、胰以及淋巴管等器官和细胞类型的形成过程中起着重要的作用。 目 …