2024年12月25日 · PSMD1 (Proteasome 26S Subunit, Non-ATPase 1) is a Protein Coding gene. Diseases associated with PSMD1 include Cystic Fibrosis and Alzheimer's Disease. Among its related pathways are Autodegradation of the E3 ubiquitin ligase COP1 and CDK-mediated phosphorylation and removal of Cdc6.

The gene PSMD1 encodes the largest non-ATPase subunit of the 19S regulator base, which is responsible for substrate recognition and binding. [6] The human PSMD1 gene has 25 exons and locates at chromosome band 2q37.1.

2024年4月5日 · PSMD1 depletion induced cell cycle arrest in G2/M phase, DNA damage and apoptosis of cancer cells, irrespective of the p53 status. PSMD1 depletion-mediated cell death was accompanied by an...

修饰的蛋白酶体 (免疫蛋白酶体) 的基本功能是加工 I 类 MHC 肽。 该基因编码 19S 调节盖的最大非 ATP 酶亚基，负责底物识别和结合。 有证据表明，这种蛋白酶体及其亚基与病毒蛋白相互作用，包括冠状病毒的蛋白。 已发现该基因的可变剪接转录本变体。 [RefSeq 提供，2020 年 8 月] The 26S Proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator.

2021年3月12日 · Two genes that were upregulated in TKI-resistant CML cells were proteasome 26S subunit, non-ATPases 1 (PSMD1) and 3 (PSMD3), both members of the 19S regulatory complex in the 26S proteasome....

PSMD1 as a prognostic marker and potential target in oropharyngeal cancer. Proteasome 26S subunit, non-ATPase 1 (PSMD1) facilitated the progression of lung adenocarcinoma by the de-ubiquitination and stability of PTEN-induced kinase 1 (PINK1).

2024年12月10日 · Title: Mitochondrial outer membrane protein MTUS1/ATIP1 exerts antitumor effects through ROS-induced mitochondrial pyroptosis in head and neck squamous cell carcinoma. Depletion of proteasome subunit PSMD1 induces cancer cell death via protein ubiquitination and DNA damage, irrespective of p53 status.

PSMD1 和 PSMD3 是 26S 蛋白酶体中 19S 调节复合物的非 ATPase 亚基，可能参与蛋白酶体底物识别和结合。在乳腺癌中，PSMD1 被证明通过诱导 p53 降解来调节细胞生长（Okumura 等人，2018 年），而 PSMD3 被证明可以保护 HER2 免受降解（Fararjeh 等人，2019 年）。

2018年1月1日 · Taken together, PSMD1 was identified as a potential gene that plays a role in the development of tamoxifen resistance in breast cancer cells. These findings will provide a new insight for the mechanism underlying endocrine therapy resistance and a prognostic and therapeutic molecular target for advanced breast cancer.

在真核细胞中，细胞质和核中大部分蛋白质通过泛素-蛋白酶体途径降解。 26S蛋白酶体是一种自分区的蛋白酶，由大约31个不同的亚基组成。 它包含一个桶状的蛋白水解核心复合物（20S蛋白酶体），在一端或两端由19S调节复合物覆盖，该复合物识别泛素化的蛋白质。 蛋白酶体降解蛋白质是MHC I类分子上呈现的大部分抗原肽的来源。 这个基因编码26S蛋白酶体的非ATP酶亚基。 [由RefSeq，2008年7月提供] 该基因暂未发现相关的转录本和蛋白质序列信息。 该模块正在开发 …