
PSMD1 Gene - GeneCards | PSMD1 Protein | PSMD1 Antibody
2024年12月25日 · PSMD1 (Proteasome 26S Subunit, Non-ATPase 1) is a Protein Coding gene. Diseases associated with PSMD1 include Cystic Fibrosis and Alzheimer's Disease. Among its related pathways are Autodegradation of the E3 ubiquitin ligase COP1 and CDK-mediated phosphorylation and removal of Cdc6.
PSMD1 - Wikipedia
The gene PSMD1 encodes the largest non-ATPase subunit of the 19S regulator base, which is responsible for substrate recognition and binding. [6] The human PSMD1 gene has 25 exons and locates at chromosome band 2q37.1.
Depletion of proteasome subunit PSMD1 induces cancer cell …
2024年4月5日 · PSMD1 depletion induced cell cycle arrest in G2/M phase, DNA damage and apoptosis of cancer cells, irrespective of the p53 status. PSMD1 depletion-mediated cell death was accompanied by an...
蛋白酶体 26S 亚基,非 ATPase 1(PSMD1)基因 | MCE
修饰的蛋白酶体 (免疫蛋白酶体) 的基本功能是加工 I 类 MHC 肽。 该基因编码 19S 调节盖的最大非 ATP 酶亚基,负责底物识别和结合。 有证据表明,这种蛋白酶体及其亚基与病毒蛋白相互作用,包括冠状病毒的蛋白。 已发现该基因的可变剪接转录本变体。 [RefSeq 提供,2020 年 8 月] The 26S Proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator.
Proteasome 26S subunit, non-ATPases 1 (PSMD1) and 3 (PSMD3 …
2021年3月12日 · Two genes that were upregulated in TKI-resistant CML cells were proteasome 26S subunit, non-ATPases 1 (PSMD1) and 3 (PSMD3), both members of the 19S regulatory complex in the 26S proteasome....
PSMD1 proteasome 26S subunit, non-ATPase 1 [ (human)]
PSMD1 as a prognostic marker and potential target in oropharyngeal cancer. Proteasome 26S subunit, non-ATPase 1 (PSMD1) facilitated the progression of lung adenocarcinoma by the de-ubiquitination and stability of PTEN-induced kinase 1 (PINK1).
PSMD1 proteasome 26S subunit, non-ATPase 1 [ Homo sapiens …
2024年12月10日 · Title: Mitochondrial outer membrane protein MTUS1/ATIP1 exerts antitumor effects through ROS-induced mitochondrial pyroptosis in head and neck squamous cell carcinoma. Depletion of proteasome subunit PSMD1 induces cancer cell death via protein ubiquitination and DNA damage, irrespective of p53 status.
蛋白酶体成分 PSMD1 和 PSMD3 的 NF-κB 依赖性激活作为对伊马 …
PSMD1 和 PSMD3 是 26S 蛋白酶体中 19S 调节复合物的非 ATPase 亚基,可能参与蛋白酶体底物识别和结合。在乳腺癌中,PSMD1 被证明通过诱导 p53 降解来调节细胞生长(Okumura 等人,2018 年),而 PSMD3 被证明可以保护 HER2 免受降解(Fararjeh 等人,2019 年)。
Proteasome 26S subunit PSMD1 regulates breast cancer cell …
2018年1月1日 · Taken together, PSMD1 was identified as a potential gene that plays a role in the development of tamoxifen resistance in breast cancer cells. These findings will provide a new insight for the mechanism underlying endocrine therapy resistance and a prognostic and therapeutic molecular target for advanced breast cancer.
Psmd1小鼠基因|Psmd1基因功能|Psmd1小鼠模型-RDDC官网
在真核细胞中,细胞质和核中大部分蛋白质通过泛素-蛋白酶体途径降解。 26S蛋白酶体是一种自分区的蛋白酶,由大约31个不同的亚基组成。 它包含一个桶状的蛋白水解核心复合物(20S蛋白酶体),在一端或两端由19S调节复合物覆盖,该复合物识别泛素化的蛋白质。 蛋白酶体降解蛋白质是MHC I类分子上呈现的大部分抗原肽的来源。 这个基因编码26S蛋白酶体的非ATP酶亚基。 [由RefSeq,2008年7月提供] 该基因暂未发现相关的转录本和蛋白质序列信息。 该模块正在开发 …