2024年12月25日 · PSMD4 (Proteasome 26S Subunit Ubiquitin Receptor, Non-ATPase 4) is a Protein Coding gene. Diseases associated with PSMD4 include Cholera and Alzheimer's Disease. Among its related pathways are Autodegradation of the E3 ubiquitin ligase COP1 and Chks in Checkpoint Regulation.

In brief, 20S sub complex presents three types proteolytic activities, including caspase-like, trypsin-like, and chymotrypsin-like activities. These proteolytic active sites located in the inner side of a chamber formed by 4 stacked rings of 20S subunits, preventing random protein-enzyme encounter and uncontrolled protein degradation.

PSMD4 drives progression of hepatocellular carcinoma via Akt/COX2 pathway and p53 inhibition. Upregulation of Rpn10 promotes tumor progression via activation of the NF-kappaB pathway in clear cell renal cell carcinoma.

2023年5月25日 · PSMD4/Rpn10 is a subunit of the 19S proteasome unit that is involved with feeding target proteins into the catalytic machinery of the 26S proteasome. Because proteasome inhibition is a common therapeutic strategy in multiple myeloma (MM), we investigated Rpn10 and found that it is highly expressed i …

26S 蛋白酶体是一种多催化蛋白酶复合物，具有由 2 个复合物、20S 核心和 19S 调节剂组成的高度有序结构。 20S 核心由 28 个不同亚基的 4 个环组成； 2 个环由 7 个α亚基组成，2 个环由 7 个β亚基组成。 19S 调节器由一个包含 6 个 ATP 酶亚基和 2 个非 ATP 酶亚基的碱基和一个包含多达 10 个非 ATP 酶亚基的盖子组成。 蛋白酶体以高浓度分布在整个真核细胞中，并在非溶酶体途径中以 ATP/泛素依赖性过程切割肽。 修饰的蛋白酶体 (免疫蛋白酶体) 的基本功能是加工 I 类 …

2023年6月19日 · In this study, transcriptome sequencing of HCC tissues and non-tumor hepatic tissues from the public database Cancer Genome Atlas (TGCA) revealed a high expression of PSMD4. Additionally, PSMD4 loss in HCC cells suppressed the tumor development in mouse xenograft model.

2024年7月7日 · PSMD4 regulates the malignancy of esophageal cancer cells by suppressing endoplasmic reticulum stress. Inhibition of PSMD4 blocks the tumorigenesis of hepatocellular carcinoma. Cai MJ, Cui Y, Fang M, Wang Q, Zhang AJ, Kuai JH, Pang F, Cui XDCai MJ, et al. Gene, 2019 Jun 20. PMID 30930224.

2021年11月5日 · 在这项研究中，我们利用生化和遗传策略以及动物模型来证明靶向 ubr psmd4 会触发抗 mm 活性，包括针对 pi 抗性 mm 细胞。 材料和方法 使用 WST/CellTiter-Glo 测定和膜联蛋白 V 染色进行细胞活力、药物敏感性和细胞凋亡测定。

2024年11月27日 · Title: PSMD4 drives progression of hepatocellular carcinoma via Akt/COX2 pathway and p53 inhibition. Upregulation of Rpn10 promotes tumor progression via activation of the NF-kappaB pathway in clear cell renal cell carcinoma.

Gene/transcipt that contains an open reading frame (ORF). Protein coding. A single transcript chosen for a gene which is the most conserved, most highly expressed, has the longest coding sequence and is represented in other key resources, such as NCBI and UniProt.