蛋白酪氨酸激酶 （protein tyrosine kinase,PTK）是一类催化 ATP 上γ- 磷酸转移 到蛋白 酪氨酸 残基 上的激酶，能催化多种底物蛋白质酪氨酸残基磷酸化，在细胞生长、增殖、分化中具有重要作用。 迄今发现的 蛋白酪 氨酸激酶中多数是属于致癌RNA 病毒 的癌 基因产物，也可由 脊椎动物 的 原癌基因 产。 根据PTK是否存在于 细胞膜受体 可将其分成非受体型和膜受体型。 因为多种控制 细胞生长因子 的细胞膜受体均有PTK活性，而且许多是原癌基因产物。 如Src家族 膜蛋白 都 …

FRK, also known as protein tyrosine kinase 5 (PTK5), is one of the three members of the BRK family kinases (BFKs) [1]. The other two members include BRK/PTK6 (breast tumour kinase) and SRMS/PTK70 (Src-related kinase lacking C-terminal regulatory tyrosine and N-terminal myristoylation sites).

2024年12月25日 · FRK (Fyn Related Src Family Tyrosine Kinase) is a Protein Coding gene. Diseases associated with FRK include Soft Tissue Sarcoma and Liver Benign Neoplasm. Among its related pathways are PIP3 activates AKT signaling and Innate Immune System.

FRK (PTK5) is a nuclear protein and may function during G1 and S phase of the cell cycle, suppressing growth. The human FRK gene maps to chromosome 6q21-q22.3 and encodes a 505 amino acid protein. The protein belongs to the TYR family of protein kinases.

Bioss Anti-PTK5 Polyclonal, Catalog # BS-6382R. Tested in Western Blot (WB), Immunocytochemistry (ICC/IF), Immunohistochemistry (Frozen) (IHC (F)), Immunohistochemistry (Paraffin) (IHC (P)) and ELISA (ELISA) applications. This antibody reacts with Human, Mouse, Rat samples. Supplied as 100 µL purified antibody (1 mg/mL).

Plasmid pTK5 from Dr. Iain Cheeseman's lab contains the insert ACTR1A and is published in Nat Cell Biol. 2012 Feb 12;14(3):311-7. doi: 10.1038/ncb2440. This plasmid is available through Addgene.

FRK was first discovered in 1993, and studies pursued thereafter attributed a potential tumour-suppressive function to the enzyme. In recent years, however, further functional characterization of the tyrosine kinase in diverse cancer types suggests that FRK may potentially play an oncogenic role as well.

PTK4, PTK5, PTK11, PTK13, and PTK17 showed significant downregulation under drought stress in leaf tissues in all three genotypes (OS-00143; Figure 6). PTKs were found to be upregulated in seeds under heat stress with 1.5 to 2.5 fold increase in expression as compared with control except PTK3, PTK9, and PTK12 (OS-00155; Figure 6).

FRK (PTK5) is a nuclear protein and may function during G1 and S phase of the cell cycle, suppressing growth. The human FRK gene maps to chromosome 6q21-q22.3 and encodes a 505 amino acid protein. The protein belongs to the TYR family of protein kinases.

The protein encoded by this gene belongs to the TYR...