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PIWI Argonaute proteins and Piwi-interacting RNAs (piRNAs) are expressed in all animal species and play a critical role in cellular defense by inhibiting the activation of transposable elements in the germline. Recently, new evidence suggests that PIWI proteins and piRNAs also play important roles in various somatic tissues, including neurons.

Piwi is an abbreviation of P-element Induced WImpy testis [a] in Drosophila. [6] Piwi proteins are highly conserved RNA-binding proteins and are present in both plants and animals. [7] Piwi proteins belong to the Argonaute/Piwi family and have been classified as nuclear proteins.

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The evolutionarily conserved Argonaute/PIWI (AGO/PIWI; a.k.a. PAZ-PIWI Domain, or PPD) family of proteins is crucial for the biogenesis and function of small non-coding RNAs (ncRNAs). This family can be divided into AGO and PIWI subfamilies.

piRNA（PIWI-interacting RNA），是一种长25～33nt的非编码RNA，通过与PIWI蛋白相互作用而发挥作用，虽然同为非编码RNA，piRNA却远没有miRNA、LncRNA、circRNA知名度高，主要是因为piRNA主要在生殖系统中表达，相…

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2018年3月3日 · Piwi is identified as the most significant protein in the presence or absence of RNaseA treatment compared with the GST control. Identified Piwi peptides cover 46% and 42% of the Piwi sequence. However, no Aub or Ago3 peptides were detected in the top 200 hits.

2023年11月7日 · This makes the odd sounding ‘PiWi,’ the abbreviation of the German-language technical term Pilzwiderstandsfähige Traubensorten, or fungal-resistant hybrid grape varieties, one of the most important new wine buzz words at Prowein 2024.