Nuclear receptor PXR targets AKR1B7 to protect mitochondrial
Moreover, PXR overexpression ameliorated the cisplatin-induced inflammatory response and accumulation of mitochondrial ROS and reversed the cisplatin-induced alterations in MMP, …
Activation of nuclear receptor pregnane-X-receptor protects …
2024年11月1日 · We found a significant decrease in both mRNA and protein levels of PXR in both human and murine aortic smooth muscle cells from AAA tissues, accompanied with …
药物代谢酶CYP450诱导机理及体外评估模型解析 - 知乎
PXR/AhR 核受体激活实验. 通常采用癌细胞系进行PXR核受体激活实验，例如采用瞬时或者稳定转染PXR和报告基因的HepG2或HuH7癌细胞，报告基因常采用如荧光素酶、氯霉素乙酰转移酶 …
CYP3A INDUCTION BY - ScienceDirect
2003年7月1日 · A series of N-hydroxyformamide tumor necrosis factor-α converting enzyme (TACE)/matrix metalloprotease (MMP) inhibitors were evaluated for their potential to induce …
PXR: a center of transcriptional regulation in cancer - PMC
Recently, microRNA (miR)-34a, miR-140-3p, miR-148a and miR-449a were found to downregulate the expression of PXR through the identification and interaction at the 3ʹ …
摘要:目的从孕烷X 受体(PXR) 对药物代谢途径的调控入手,在代谢性药物相互作用、PXR 在CYP3A4调控中的作用及其调控机制等方面作分析和阐述。 方法结合近年来国内外相关文献进 …
Indole-3-propionic Acid 通过调节 PXR 信号通路减轻新生大鼠 HI
结果表明，rBMECs 中 PXR 的过表达可以显着抵消连接蛋白的减少，并下调 OGD 损伤引起的增加的 p-IκB-α 和 p-NF-κB。 然而，IPA 的保护作用被 PXR 的拮抗剂逆转。
The Pregnane X Receptor and Indole-3-Propionic Acid Shape the ...
2023年1月1日 · Fibrosis is a common complication of inflammatory bowel diseases (IBDs). The pregnane X receptor (PXR) (encoded by NR1I2) suppresses intestinal inflammation and has …
Structures of selected N-hydroxyformamide TACE/MMP inhibitors.
A series of N-hydroxyformamide tumor necrosis factor-alpha converting enzyme (TACE)/matrix metalloprotease (MMP) inhibitors were evaluated for their potential to induce human …
Associations between Pregnane X Receptor and Breast Cancer …
2020年10月15日 · While PXR has been linked to some anti-apoptotic mechanisms in breast cancer, studies have indicated that PXR induces apoptosis in the p53 wild-type breast cancer …