2004年2月1日 · We have conducted a survey of proline‐rich (PxxP) motifs in the proteomes of human, mouse, yeast, Mycobacteriumtuberculosis and Plasmodiumfalciparum. Our analyses reveal a strikingly high occurrence of these motifs in each organism, suggesting a wide dependence on protein–protein interaction networks in cellular systems.

2023年8月9日 · Therefore, we propose that the central PxxP motif in AHPs provides dynamic conformational behavior in aqueous and membrane-mimetic environments, enhances binding to anionic membranes, and facilitates translocation across lipid bilayers, resulting in improved antibacterial potency and selectivity.

2010年11月22日 · Our complex structure reveals a unique type of SH3 interaction based on recognition of tandem PxxP motifs in the ligand. Strikingly, the specificity pocket of IRTKS SH3 has evolved to accommodate a polyproline type II helical peptide analogously to docking of the canonical PxxP by the conserved IRTKS SH3 proline-binding pockets.

The purpose of this study is to determine whether the proline-rich (PXXP) domain of BAG3 is necessary for its cellular protection against hypoxia-reoxygenation (H/R) stress by binding to its chaperone, heat shock cognate 71 kDa protein (HSC70).

2002年8月8日 · A PxxP motif and a non-PxxP motif in the same polypeptide chain can generate a protein ligand with high affinity and specificity via the multivalent binding mechanism, as seen in p67 phox –p47 phox and Csk–PEP.

2001年1月1日 · Human immunodeficiency virus (HIV) and simian immunodeficiency virus Nef proteins contain a conserved motif with the minimal consensus (PxxP) site for Src homology region 3 (SH3)-mediated protein-protein interactions.

The present study was conducted to determine whether avian reovirus (ARV) activates the phosphatidylinositol 3-kinase-dependent Akt (PI3K/Akt) pathway according to the PXXP or YXXXM motifs of σA and σNS proteins. Gene splicing by overlap extension PCR was used to change the PXXP or YXXXM motifs of the σA and σNS genes.

人免疫缺陷病毒（HIV）和猿猴免疫缺陷病毒Nef蛋白包含一个保守的基序，具有最小的Src同源区域3（SH3）介导的蛋白-蛋白相互作用的共有（PxxP）位点。

2016年8月11日 · Here, we describe a new pathway for maintaining protein homeostasis mediated by the proteasome shuttle factor UBQLN2. The 26S proteasome degrades polyubiquitylated substrates by recognizing them through stoichiometrically bound ubiquitin receptors, but substrates are also delivered by reversibly bound shuttles.

2004年3月1日 · We have conducted a survey of proline-rich (PxxP) motifs in the proteomes of human, mouse, yeast, Mycobacterium tuberculosis and Plasmodium falciparum. Our analyses reveal a strikingly high...