Methods: The study was performed as a randomized, placebo-controlled, double-blind, cross-over study. 50 men with moderate ED received a combination of Pycnogenol®, roburins, L-arginine, L-citrulline or placebo. Sexual wellness was evaluated by …

Clinically, the combination of Pycnogenol ® and L-arginine (PAL) has been evaluated in several randomized controlled trials (RCTs). Existing research results showed that the combined treatment of PAL had inconsistent results in improving …

We conclude that oral administration of L-arginine in combination with Pycnogenol causes a significant improvement in sexual function in men with ED without any side effects. Penile erection requires the relaxation of the cavernous smooth muscle, which is triggered by nitric oxide (NO).

Pycnogenol containing Prelox may lead, via regeneration of DDAH II activity, to lower ADMA concentrations and, in turn, to enhancement of e-NOS activity. In addition to this DDAH II based mechanism, the L-arginine aspartate component of Prelox may contribute to restore e-NOS activity by a competitive displacement of ADMA from the L-arginine

Objectives: To test the efficacy and safety of oral L-citrulline supplementation in improving erection hardness in patients with mild erectile dysfunction (ED). L-arginine supplementation improves nitric oxide-mediated vasodilation and endothelial function; however, oral administration has been hampered by extensive presystemic metabolism.

Another combination of 80 mg Pycnogenol, 1.92g L-arginine, 1.2g citrulline and 40mg French oak wood extract (Prelox ® R) a day was tested on 50 men with confirmed erectile dysfunction (ED scores 11-17) [31]. L-citrulline was added because it increases plasma L-arginine concentrations more effectively than L-arginine itself [32].

PDE-5 inhibitor with l-arginine for erectile dysfunction and comparing with PDE-5 inhibitor alone: one for sildenafil15 and one for vardenafil.17 Both the studies showed a small but significant advantage of adding l-arginine to the treatment. l-arginine and l-citrulline l-citrulline, a semi-essential amino acid like l-arginine, can be

METHODS: The study was performed as a randomized, placebo-controlled, double-blind, cross-over study. 50 men with moderate ED received a combination of Pycnogenol®, roburins, L-arginine, L-citrulline or placebo. Sexual wellness was evaluated by the International Index of Erectile Function (IIEF).

To increase the amount of arginine converted to NO, take 50 mg to 100 mg of pycnogenol, along with your L-arginine. As an alternative to erectile dysfunction medicine, take arginine and pycnogenol 30 to 60 minutes before sexual activity.

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