2024年12月25日 · PYCR1 (Pyrroline-5-Carboxylate Reductase 1) is a Protein Coding gene. Diseases associated with PYCR1 include Cutis Laxa, Autosomal Recessive, Type Iib and Cutis Laxa, Autosomal Recessive, Type Iiib. Among its related pathways are Glutamate and glutamine metabolism and superpathway of L-citrulline metabolism.

Pyrroline-5-carboxylate reductase 1, mitochondrial is an enzyme that in humans is encoded by the PYCR1 gene. [5] [6] This gene encodes an enzyme that catalyzes the NAD(P)H-dependent conversion of pyrroline-5-carboxylate to proline. This enzyme may also play a physiologic role in the generation of NADP(+) in some cell types.

Pyrroline-5-carboxylate reductase 1 (PYCR1) promotes the proliferation and metastasis of liver cancer (LC) cells. The expression of PYCR1 in LC is regulated by DNA methylation. Knocking down or inhibiting PYCR1 inhibits glycolysis as well as the PI3K/AKT/mTOR and MAPK/ERK pathways in LC cells.

该基因编码一种酶，该酶催化 NAD (P) H 依赖性吡咯啉-5-羧酸盐转化为脯氨酸。 这种酶也可能在某些细胞类型的 NADP (+) 生成中发挥生理作用。 该蛋白质形成均聚物并定位于线粒体。 可变剪接导致多个转录本变体。 [RefSeq 提供，2013 年 8 月] This gene encodes an Enzyme that catalyzes the NAD (P)H-dependent conversion of pyrroline-5-carboxylate to proline. This Enzyme may also play a physiologic role in the generation of NADP (+) in some cell types.

吡咯啉-5-羧酸还原酶-1 (Pyrroline-5-Carboxylate Reductase-1, PYCR1)是一种线粒体酶，其基因突变可导致人类皮肤松弛症。 近年研究证明PYCR1能通过影响脯氨酸代谢发挥促进肿瘤生长增殖的作用。 PYCR1在多种恶性肿瘤中高表达，且其表达水平与患者预后负相关。 因此，PYCR1可能可以作为一种新型标志物，应用于肿瘤的诊断和预后，并有望成为肿瘤治疗的新靶点。 引用本文: 张丽红, 王超超. 吡咯啉-5-羧酸还原酶-1在恶性肿瘤中的研究进展 [J/OL] . 中华临床实验室管理电 …

A novel mutation in PYCR1 causes an autosomal recessive cutis laxa with premature aging features in a family. The phenotype caused by PYCR1 mutations corresponds to geroderma osteodysplasticum rather than ARCL2B. Mutations in PYCR1 …

PYCR1 (pyrroline-5-carpoxylate reductase-1，吡咯啉-5-羧酸还原酶-1)，是P5C (pyrroline-5-carpoxylate)转化为脯氨酸的依赖NADP的关键酶，位于染色体17q25.3，其变异会导致一种使病人出现早衰的罕见皮肤病 [4 - 5]。 PYCR1在19种不同肿瘤中均呈高表达...

PYCR 催化 Δ 1 - 吡咯啉-5-羧酸盐依赖 NAD (P)H 还原为脯氨酸，并形成脯氨酸代谢循环的还原半部分。 我们综述了PYCR的三维结构、生物化学、抑制作用和癌症生物学方面的研究。 为了提供癌症中PYCR 基因上调的全局视图，我们挖掘了 RNA 转录本数据库来分析 28 种癌症类型中的差异基因表达。 该分析揭示了PYCR 基因，尤其是 PYCR1 的强烈、广泛的上调。 总而言之，过去 20 年的研究为 PYCR 作为癌症治疗靶点提供了令人信服的理由。 最后，我们讨论了该领域的一些 …

吡咯啉-5-羧酸还原酶1（Pyrroline-5-carboxylatereductase1,PYCR1）参与脯氨酸代谢，催化吡咯啉-5-羧酸还原为脯氨酸，脯氨酸的代谢在肿瘤的发生中非常重要。 前人的研究发现，PYCR1在多种恶性肿瘤中呈现高表达，在前列腺癌细胞中敲除PYCR1能够显著抑制细胞生长和克隆形成，抑制PYCR1表达的乳腺癌细胞的侵袭性减弱，在食管鳞癌中与PYCR1形成的蛋白质复合物可以调控肿瘤细胞的增殖及转移。 然而，PYCR1在NSCLC中的功能研究还不多，本研究旨在揭 …

In this study, we show that mitochondrial proline synthesis, specifically through PYCR1 activity, is essential to support hypoxic metabolism and viability. Loss of PYCR1 in vivo results in an unsustainable compensatory increase in respiration, cell death, and decreased tumor growth. We therefore propose that inhibition of PYCR1 is a viable ...