2024年12月25日 · QSOX1 (Quiescin Sulfhydryl Oxidase 1) is a Protein Coding gene. Diseases associated with QSOX1 include Prostate Cancer. Among its related pathways are Response to elevated platelet cytosolic Ca2+ and Innate Immune System.

QSOX1 is a multi-domain disulfide catalyst. Unlike other disulfide catalysts, QSOX1 can both generate disulfides de novo and catalyze dithiol / disulfide exchange. The de novo disulfide bond formation is catalyzed by the ERV1 domain that contains a FAD co-factor that allows depositions of electrons onto the terminal electron acceptor, typically ...

2024年10月21日 · Quiescent fibroblast-derived quiescin sulfhydryl oxidase 1 (QSOX1) promotes the expression of PD-L1 and its own expression in DCSCs by elevating the level of reactive oxygen species. Additionally, high QSOX1 in the dormant tumor niche contributes to the exclusion of CD8 + T cells.

2021年3月20日 · 氢巯基氧化酶1 (Sulfhydryl oxidase 1, QSOX1) 是一种能够催化蛋白分子中的自由巯基生成二硫键的酶类，参与蛋白质翻译后折叠影响其生物学功能。 课题组前期研究表明，QSOX1在肝癌中发挥了抑癌的作用，并与肝癌的良好预后相关，但QSOX1在肝癌中参与的生物 …

QSOX1 is a potential new prognostic marker which may prove of use in the staging of breast tumours and the stratification of breast cancer patients. QSOX1 activity was required for incorporation of laminin into the extracellular matrix (ECM) synthesized by fibroblasts, and ECM produced without QSOX1 was defective in supporting cell-matrix adhesion.

Quiescin sulfhydryl oxidase 1 (QSOX1) is an enzyme overexpressed by many different tumor types. QSOX1 catalyzes the formation of disulfide bonds in proteins. Because short hairpin knockdowns (KD) of QSOX1 have been shown to suppress tumor growth and invasion <i>in vitro</i> and <i>in vivo</i>, we hy …

该基因编码的蛋白质包含硫氧还蛋白和 ERV1 的结构域，它们是两个长期存在的基因家族的成员。 随着成纤维细胞开始退出增殖周期并进入静止期，基因表达被诱导，表明该基因在生长调节中起重要作用。 已发现该基因的两个转录变体编码两种不同的亚型。 [RefSeq 提供，2008 年 7 月] This gene encodes a protein that contains domains of thioredoxin and ERV1, members of two long-standing gene families.

Quiescin sulfhydryl oxidases (QSOXs) catalyze the formation of disulfide bonds in peptides and proteins, and in vertebrates comprise two proteins: QSOX1 and QSOX2. QSOX1, the most extensively studied type, has been implicated in protein folding, production of extracellular matrix, redox regulation, …

2025年1月4日 · Title: High expression of QSOX1 is associated with tumor invasiveness and high grades groups in prostate cancer. High QSOX1 expression is a strong and independent factor of reduced survival in breast cancer and may represent a biomarker for aggressive disease and a potential treatment target

QSOX1 catalyzes disulfide formation, by reducing molecular oxygen to hydrogen peroxide. Heckler et al. demonstrated, in recombinant human QSOX1, that the first two CxxC motifs are essential to oxidize model substrates, such as dithiothreitol (DTT) or reduced RNAse, since single mutations in the cysteine residues of the CxxC motifs result in ...