2020年6月25日 · Reduced wall shear stress enhances RBC binding to VWF 4 and stasis increases venous thrombosis risk; however, the extent of flow reduction during venous …

2025年2月5日 · Despite their limitations, these models, which involve development of thrombi that share many of the hallmarks of human thrombi, have revealed important roles for von …

In thrombosis and hemostasis, VWF is an extremely well-studied polymeric protein known for capture of flowing platelets via glycoprotein Ibα. Smeets et al. found VWF immobilized on a …

2020年12月17日 · In particular, ABO affects multiple aspects of von Willebrand factor (VWF) biology. In keeping with their reduced thrombotic risk, plasma VWF levels are ∼25% lower in …

2023年2月20日 · Von Willebrand factor (vWF) is a glycoprotein crucial to primary hemostasis through platelet and subendothelial collagen adhesion and the intrinsic coagulation cascade …

Von Willebrand factor (VWF) is a large multimeric glycoprotein produced in endothelial cells and megakaryocytes and present in subendothelial matrix, blood plasma and platelets. VWF …

VWF binds and stabilizes FVIII (fac-tor VIII) in circulation and promotes platelet recruitment and adhesion to the endothelium. Using a flow-based system with surface-immobilized plasma and …

2022年7月12日 · Unusually large von Willebrand factor (Vwf) multimers increase adhesion of sickle erythrocytes (Rbc) to endothelial-cells (Ec) under controlled flow [abstract]

Broad expression in fat (RPKM 93.4), lung (RPKM 58.7) and 16 other tissues. 该基因编码参与止血的糖蛋白。 编码的前原蛋白在组装成大的多聚体复合物后被蛋白水解加工。 这些复合物在 …

血管性血友病因子，英文名称von Willebrand Factor, vWF，是由第 12号染色体 的 短臂 所编码的 糖蛋白。 vWF可同时与 胶原纤维 和 血小板 结合，当血管破裂时大量血小板以vWF为中介， …