A brave new world of RNA-binding proteins - Nature
2018年1月17日 · In this Review, we discuss these new RBPs and the emerging understanding of their unexpected modes of RNA binding, which can be mediated by intrinsically disordered …
Interaction of PKR with single-stranded RNA | Scientific Reports …
2017年6月13日 · We propose that bivalent interactions with the double stranded RNA binding domain and the basic region underlie the ability of RNAs containing limited structure to …
RNA-binding proteins and post-transcriptional gene regulation
ADAR2 and PKR are two RBPs that have similar RNA-binding domains, the dsRBD, but differ in their auxiliary domains and their associated functions. ADAR2 combines its dsRBD with a …
RBP–RNA interactions in the control of autoimmunity and
2023年1月5日 · In this review, we summarize and discuss the functions of RBP–RNA interactions in controlling aberrant autoimmune inflammation and their potential as biomarkers and …
PKR Senses Nuclear and Mitochondrial Signals by Interacting with ...
2018年9月20日 · Protein kinase RNA-activated (PKR), also known as eukaryotic initiation factor 2-alpha kinase 2 (EIF2AK2), is a ubiquitously expressed enzyme that initiates immune …
国人高分综述 | Theranostics：环状RNA-蛋白质相互作用：功能， …
2021年4月20日 · RBP是一类通过介导RNA的成熟，转运，定位和翻译而与RNA代谢过程相关的蛋白质，这些蛋白质甚至参与形成核糖核蛋白复合物。尽管circRNA序列的生物信息学分析已预 …
重磅综述：环状RNA的调控机制和细胞功能 - circRNA论坛
剪接和可变剪接都受剪接体功能相关的蛋白和与侧翼内含子顺式元件结合的rna结合蛋白(rbp)的调控。除了ics调节反向剪接的作用外，许多rbp还控制circrna的产生。使用表达载体实验显示， …
Regulatory network mediated by RBP-J/NFATc1-miR182 controls ...
Our findings in this study revealed the presence of the RBP-J/NFATc1-miR182-PKR/FoxO3 network in human RA and its significant correlation with ex vivo osteoclastogenesis. The RA …
应激颗粒生命周期图 | Cell Signaling Technology
通常，起始前复合体 (PIC) 因蛋白激酶 R (PKR)、蛋白激酶 RNA 样 ER 激酶 (PERK)、通用控制非去阻遏 2 (GCN2) 或血红素调节的抑制剂 (HRI) 使 eIF2α 磷酸化而受到抑制。 1 此外，mTOR …
The role of host eIF2α in viral infection - Virology Journal
2020年7月23日 · General control nonderepressible-2 (GCN2), protein kinase R-like endoplasmic reticulum kinase (PERK), double-stranded RNA (dsRNA)-dependent protein kinase (PKR) and …