The following parameters are required from pathologic examination in order to calculate Residual Cancer Burden (RCB) after neoadjuvant treatment: The largest two dimensions (mms) of the residual tumor bed in the breast (largest tumor bed if multicentric disease)

The residual cancer burden (RCB) index measures the amount of cancer remaining in the breast and nearby lymph nodes after neoadjuvant therapy (treatment given before surgery). The index is used for the most common types of breast cancer, including invasive ductal carcinoma , invasive lobular carcinoma , invasive apocrine carcinoma , and ...

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2025年3月6日 · An RCB score is determined using information on the size of the tumor and the extent of tumor cells in the breast and axillary lymph nodes after neoadjuvant therapy. The higher the RCB score, the more residual invasive breast cancer there is in the breast and lymph nodes:

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RCB index is a reliable prognostic score. RCB accurately identifies patients at a high risk of recurrence (RCB-III) with TNBC or HER2 -positive BC who must be offered second-line adjuvant therapies. Neoadjuvant chemotherapy (NAC), i. e. chemotherapy before surgery, is currently being used in poor prognosis breast carcinoma.

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