2023年9月1日 · In this work, a ginsenoside Rg3 (Rg3)-functionalized biomimetic nanoplatform is fabricated by encapsulating arsenic trioxide (ATO) and chlorin e6 (Ce6) into exosomes, denoted as Rg3-Exo/ATO@Ce6, to ameliorate photoimmunotherapy via reprogramming the tumor microenvironment (TME).

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2022年2月11日 · Here, a multifunctional Rg3 liposome loading with docetaxel (Rg3-Lp/DTX) was developed, in which Rg3 was proved to intersperse in the phospholipid bilayer and exposed its glycosyl on the liposome surface. Therefore, it exhibited much higher CTC-capturing efficiency via interaction with glucose transporter 1 (Glut1) overexpressed on CTCs.

2023年6月1日 · Rg3 ameliorated Ca 2+ circulatory abnormalities and demonstrated the potential for SERCA2a SUMOylation as a new therapeutic target for Rg3 in the treatment of heart failure, based on experiments in a transverse aortic constriction (TAC)-induced animal model of …

2024年4月22日 · Ginsenoside Rg3, the primary constituent of Korean red ginseng (steamed Panax ginseng CA Meyer), has shown therapeutic potential in combating inflammatory and metabolic diseases. However, it...

2023年11月10日 · We identified that the herbal monomer ginsenoside Rg3 (Rg3) can shape the gut microbiota composition, enriching robust short-chain fatty acid (SCFA)-producing Blautia spp....

Rg3 inhibits cell proliferation and induces apoptosis via different effector molecules and pathways, in MDA-MB-231 cell line [30,31]. Changes in specific molecules involved in signalling pathways upon exposure of the cells to Rg3 is shown in this figure.

2018年3月22日 · Recent experiments have demonstrated that ginsenoside Rg3, which contains 2 neighbouring hydroxyl groups near and on the chiral centre C-20, can act as a natural ligand of PPARγ. 10 Angiogenesis assay found that both Rg3 stereoisomers can induce differential angiogenesis effects via PPARγ, and the PPARγ agonist activity of 20(S)-Rg3 is 10 ...

2019年2月28日 · The ginsenoside Rg3 and Rh2 (LKT Labs, St. Paul, Minnesota, USA), Korean Red Ginseng (KRG) extract (kindly donated by Korea Ginseng Co., Daejon, Korea), and 5-Aza-2′-deoxycytidine (5-Aza; Sigma-Aldrich, St. Louis, MO, USA) were used to treat the cells in a 60-mm culture dish at a confluence of 50-70%.

We found that Rg3 treatment (25, 50, 100 μg/ml) inhibited cell migration and invasion by wound-healing and transwell assays. Rg3 could significantly alter EMT marker proteins with increased E-cadherin, but decreased Snail, N-cadherin and Vimentin expression.