RIP1 inhibition protects retinal ganglion cells in glaucoma models …
2024年10月24日 · RIP1 inhibition reduces RGC death and axonal degeneration following IRI in mice expressing OPTN-WT and OPTN-E50K variant mice. We demonstrate that RIP1 …
Ripa-56 protects retinal ganglion cells in glutamate-induced …
2024年2月15日 · Ripa-56, a new kind of receptor-interacting protein kinase (RIPK) 1 inhibitor that has been found to be more potent and devoid of off-target effects compared to Necrostatin-1 …
GSK872 和 necrostatin-1 通过抑制谷氨酸诱导的青光眼视网膜兴奋性毒性模型中的 RIP1…
通过免疫荧光和蛋白质印迹测量RIP1、RIP3、MLKL和NLRP3炎症小体相关蛋白的表达水平。 我们发现谷氨酸兴奋性毒性通过在体内和体外激活 RIP1/RIP3/MLKL 通路诱导 RGCs 坏死性凋 …
RIP1 kinase mediates angiogenesis by modulating macrophages …
2019年11月19日 · Here, we show that RIP1 is abundantly expressed in infiltrating macrophages during angiogenesis, and genetic or pharmacological inhibition of RIP1 kinase activity using …
GSK872 and necrostatin-1 protect retinal ganglion cells against ...
We found that glutamate excitotoxicity induced necroptosis in RGCs through activation of the RIP1/RIP3/MLKL pathway in vivo and in vitro. Administration of the RIP3 inhibitor GSK872 and …
RIP3-mediated microglial necroptosis promotes …
2023年3月29日 · We found that activated microglia triggered an inflammatory cascade through a process called necroptosis, a newly discovered pathway of regulated cell death. In the diabetic …
GSK872 and necrostatin-1 protect retinal ganglion cells against ...
2022年10月26日 · Our findings suggest that the RIP1/RIP3/MLKL pathway mediates necroptosis of RGCs and regulates NLRP3 inflammasome activation induced by glutamate excitotoxicity. …
RIP1在细胞程序性死亡中作用的研究进展 - 章 - 临床与病理杂志
近期研究发现受体相互作用蛋白 (receptor-interacting protein，RIP)是细胞生存和死亡的重要交叉点，在细胞的凋亡与存活、程序性坏死等过程中发挥着关键性的作用。 RIP1为RIP家族中的第 …
RIP3 and RIP1. A: Western blot of RIP3 and RIP1 in eye
A: Western blot of RIP3 and RIP1 in eye-cups and retinas from normal, MOCK-i n fe ct ed (CT R) a nd MCMV-injected IS (MCMV) mice at day 10 p.i. B: Ratio of RIP3 and cleaved RIP1 to β-actin.
Protective effect of RIPK1-inhibitory compound in
2019年3月1日 · The eye drop administration of RIPK1-inhibitory compound (RIC) prevents RPE loss in in vivo models of dry AMD. RIPK1-dependent necrosis, necroptosis, might be a …