2015年5月8日 · RIP3 mRNA was highly expressed in the tumors of most of the 5-AD-treated mice, irrespective of whether or not mice were treated with doxorubicin (Figure 7E) and RIP3 protein was clearly...

RIP3比较特别，其C端结构是RHIM，且缺少中间结构域； RIP4 和 RIP5：AD-ID。 RIP4 和 RIP5 的C端结构都是锚蛋白域（ankyrin domains，AD），但是其中间结构则是ID； RIP6 和 RIP7 的结构与其它 RIP 家族成员相关性较弱。 除了包含 RIP 家族共有的激酶结构域和锚蛋白重复序列，还包含一些其他结构域，如富含亮氨酸重复序列和 WD40 重复序列 [3]。 （1）RIP1 中间域（ID）的 Lys377 是泛素分子 Lys63 介导的一个重要的泛素化 RIP1 位点。 RIP1位点发生泛素化 …

2021年9月15日 · 细胞坏死是一种 Caspase 非依赖性的、受调控的细胞死亡形式，由受体相互作用的丝氨酸 / 苏氨酸蛋白激酶（RIPs）和混合谱系激酶结构域样蛋白（MLKL）的激活驱动。 细胞坏死在各种病理形式的细胞死亡中发挥作用，包括缺血性脑损伤、神经退行性疾病和病毒感染。 坏死进程：正常细胞 – 细胞肿胀 – 细胞膜分解 – 释放细胞内容物。 细胞坏死进程中至关重要的一些蛋白包括： 受体. 与配体结合后，TNFα 受体超家族、T 细胞受体（TCRs）、干扰素受 …

2016年1月4日 · Here we show that receptor-interacting protein 3 (RIP3) triggers myocardial necroptosis, in addition to apoptosis and inflammation, through activation of Ca 2+ -calmodulin–dependent protein...

2009年7月17日 · By activating key enzymes of metabolic pathways, RIP3 regulates TNF-induced reactive oxygen species production, which partially accounts for RIP3's ability to promote necrosis. Our data suggest that modulation of energy metabolism in response to death stimuli has an important role in the choice between apoptosis and necrosis.

2015年6月6日 · Receptor-interacting protein kinase-3 (RIP3, or RIPK3) is an essential protein in the “programmed”, or “regulated” necrosis cell death pathway that is activated in response to death receptor ligands and other types of cellular stress.

2014年11月20日 · Receptor-interacting protein kinase 3 (RIP3 or RIPK3) has emerged as a central player in necroptosis and a potential target to control inflammatory disease. Here, three selective small-molecule compounds are shown to inhibit RIP3 kinase-dependent necroptosis, although their therapeutic value is unde …

Receptor-interacting kinase 3 (RIP3) is a critical regulator of programed necrosis and is regulated by post-translation modifications. In this review, Moriwaki and Chan discuss the underlying mechanisms that promote RIP3-dependent necrosis and its ...

1999年6月11日 · RIP3 binds RIP through its unique C-terminal segment and by virtue of this interaction is recruited to the tumor necrosis factor (TNF) receptor-1 signaling complex. Previous studies have shown that RIP mediates TNF-induced activation of the anti-apoptotic NF-κB pathway. RIP3, however, attenuates both RIP and TNF receptor-1-induced NF-κB activation.

催化活性: ATP + a protein = ADP + a phosphoprotein 功能: Rip3是控制坏死信号通路的关键因子。 在诱导细胞坏死时,Rip3 与Rip1 相互作用,并使其磷酸化。 Rip3通过与一些代谢酶结合刺激三羧酸循环和氧化磷酸化,导致ROS的产生,从而诱发细胞坏死。