识别胞质内RNA的蛋白家族叫做RIG-I-like receptor (RLR)。RLR在结构上拥有保守的DExH motif（在helicase domain中)，因此属于DEAD-box家族蛋白（这类蛋白含有保守的DEAD氨 …

一般认为，PRR包括四类： Toll-like receptors (TLRs)、retinoic acid-inducible gene-I (RIG-I)-like receptors (RLRs)、nucleotide oligomerization domain (NOD)-like receptors (NLRs)、C-type …

2021年8月4日 · Most PRRs in the innate immune system of vertebrates can be classified into the following five types based on protein domain homology: Toll-like receptors (TLRs), nucleotide …

tlr是病原体检测中至关重要的传感器，因此识别和表征免疫细胞表面的tlr表达对于研究病毒清除的细胞机制具有重要意义。 流式细胞仪通常是分析免疫细胞TLR谱的首选方法。

In this review, we provide a concise overview of TLRs, NLRs, and RLRs: their structure, functions, signaling pathways, and regulation. We also describe various ligands for these receptors and …

Upon recognition of these nucleic acid species, TLRs and RLRs recruit specific intracellular adaptor proteins to initiate signaling pathways culminating in activation of NF-kappaB, MAP …

几类 PRRS，包括 Toll 样受体 (TLR)、NOD 样受体 (NLR) 和 RIG-I 样受体 (RLR)，可识别不同的微生物成分并直接激活免疫细胞。 TLRs是跨膜受体，而NLRs和RLRs是细胞内分子。 将免疫 …

2012年5月20日 · We found here that the activation of cytosolic RIG-I-like receptors (RLRs) resulted in the selective suppression of transcription of the gene encoding the p40 subunit of …

2024年4月9日 · Toll-like receptors (TLRs) are an evolutionarily conserved family in the innate immune system and are the first line of host defense against microbial pathogens by …

2012年5月20日 · We found here that the activation of cytosolic RIG-I-like receptors (RLRs) resulted in the selective suppression of transcription of the gene encoding the p40 subunit of …