CRBN Structural Changes, Copy Number Changes and COP9 …
2022年11月15日 · Here we investigated at the single cell level the transcriptome (scRNA) and genome copy number alterations (CNV) of primary MM cells from patients treated with the …
Science | 靶向蛋白降解途径突破，几乎可用于任何疾病相关蛋白
2022年11月22日 · Cereblon（CRBN）是细胞中主要蛋白质处理系统的一部分。 该系统用称为泛素的分子标记靶向蛋白质，有效地标记蛋白质，以通过称为蛋白酶体的流动蛋白质分解复合物 …
Multiomic Analysis of Cereblon Expression and Its Prognostic …
Analysis of genes that are commonly correlated with CRBN expression among KIRC, LUAD, and SKCM samples elucidated the potential CRBN-associated mechanisms of cancer progression. …
Role of cereblon in angiogenesis and in mediating the …
Cereblon (CRBN) is a substrate recruiter element of the E3 cullin 4-RING ubiquitin ligase complex, and a binding target of immunomodulatory agents (IMiDs). CRBN is responsible for …
Cereblon ligands and functionalized intermediates - Enamine
Cereblon (CRBN) is one of the most explored E3 ligases extensively used to construct PROTACs, search for new Molecular Glues, and develop functionalized tool compounds. The most …
Mutations in CRBN and other cereblon pathway genes are …
2021年8月9日 · In the case of CRBN, an in vitro site-directed mutagenesis study on CRBN TBD has shown that mutation of any of the 4 cysteines involved in the Zn finger formation led to …
<br>用于靶向蛋白质降解的新型 Cereblon 结合剂的 ... - X-MOL
2023年11月22日 · 调节 cereblon (CRBN) 结合物的化学成分是试图劫持这种 E3 连接酶功能的蛋白质降解剂优化过程中的关键步骤。 微小的结构变化可能会对这些化合物的整体特征产生深远 …
Design of a Cereblon construct for crystallographic and …
2024年1月20日 · The ubiquitin E3 ligase cereblon (CRBN) is the target of therapeutic drugs thalidomide and lenalidomide and is recruited by most targeted protein degraders (PROTACs …
Cereblon is recruited to aggresome and shows cytoprotective …
2015年9月4日 · A causative gene for a mild type of autosomal recessive nonsyndromic intellectual disability, cereblon (CRBN), was identified on chromosome 3p26.2 from a Western …
CRBN分子胶药效差异的结构基础 - 知乎 - 知乎专栏
CRBN类分子胶，这里指来那度胺、泊马度胺等 (IMiD)，以及由它们衍生来的新一代分子 (BMS称之为 CELMoD)。 图1是文章比较的三个分子，活性及药效从左到右依次增强。第一个是上市 …
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