2022年3月14日 · The National Institute of Allergy and Infectious Diseases (NIAID), part of the National Institutes of Health, has launched a Phase 1 clinical trial evaluating three experimental HIV vaccines based on a messenger RNA (mRNA) platform—a technology used in several approved COVID-19 vaccines.

3 天之前 · 加拿大滑铁卢大学的科研团队正在采用RNA技术开辟一条抗击人类免疫缺陷病毒（HIV）的新途径。该校药剂学副教授Emmanuel Ho领导的研究小组开发了一 ...

2022年8月19日 · Vaccination with a SARS-CoV-2 mRNA vaccine revealed HIV hiding in immune cells in blood from people with HIV, according to lab research led by Weill Cornell Medicine investigators. The findings, published Aug. 19 in Nature Communications, identify new tools for evaluating treatment approaches in development aimed at curing HIV.

In this review, we discuss the types of mRNA vaccine, along with development, delivery, advantages, challenges, and how we are working to overcome these challenges. Keywords: hiv, vaccine, lipid nanoparticles, pandemic, mrna.

Human immunodeficiency virus 1 (HIV-1) is an RNA virus and the causative agent of acquired immunodeficiency syndrome (AIDS), which is one of the most devastating viral pandemics in history. More and more studies have shown that HIV has RNA modifications and regulation of its gene expression during infection and replication.

Newly synthesized viral RNA falls under three main categories: (1) unspliced RNA which acts as precursor for Gag and gag-pol polyprotein; (2) partially spliced mRNA (~5 kb) which encodes for Env, Vif, Vpu, and Vpr proteins; and (3) small but multiple spliced mRNAs (1.7–2.0 kb) which encode for Rev, Tat, and Nef.

2025年1月16日 · Scientists have unveiled insights into how HIV-1, the virus responsible for AIDS, skillfully hijacks cellular machinery for its own survival. By dissecting the molecular interplay between the...

Gene therapy is considered a feasible approach for the treatment and prevention of HIV/AIDS. Targeting both viral genes and host dependency factors can interfere with the viral lifecycle and prevent viral replication. A number of approaches have been taken to target these genes, including ribozymes, …

The biotech firm, along with nonprofit partner IAVI, the International AIDS Vaccine Initiative, announced in late January that researchers had administered the first doses of an investigational mRNA HIV vaccine to volunteers in a phase 1 clinical trial.

2022年2月14日 · The viral genomic RNA of the human immunodeficiency virus (HIV) encompasses nine genes encoding in less than 10 kb all proteins needed for replication in susceptible host cells. To do so, the genomic RNA undergoes complex alternative splicing to facilitate the synthesis of the structural, accessory, and regulatory proteins.