In this study, we aimed to clarify the tumor suppressor role of Wnt5a in leukemogenesis. In particular, we focused on Ror2 functioning as a Wnt5a receptor to mediate noncanonical Wnt signaling, which inhibits canonical Wnt signaling in K562 cells.

2023年12月20日 · In zebrafish embryos, active complexes of Wnt5b and its membrane-bound receptor Ror2 are transported between cells via cellular protrusions called cytonemes to initiate paracrine Wnt5b signalling...

2009年10月30日 · Emerging evidence suggests that Wnt5a can inhibit Wnt/β-catenin signaling through interaction with the receptor Ror2. The Ror2 protein belongs to the receptor tyrosine kinase superfamily and contains several recognizable structural motifs.

2024年4月8日 · Ror-family receptors, Ror1 and Ror2, function primarily as receptors or co-receptors for Wnt5a to activate the non-canonical Wnt signaling, including the Wnt/planar cell polarity (PCP) pathway, and inhibit the canonical Wnt signaling (Wnt/β-catenin pathway), depending on the cellular context.

Conversely, the overexpression of Wnt5a inhibited ABCA1 expression, facilitated cholesterol accumulation, impared cholesterol efflux, promoted NF-κB nuclear translocation and the inflammatory cytokines secretion. Moreover, the knockdown of Ror2 increased ABCA1 expression and reduced Wnt5a-induced cholesterol accumulation and inflammatory ...

2009年10月5日 · We show here that increases in Wnt5A cause increases in ROR2 expression, as well as the PKC-dependent, clathrin-mediated internalization of ROR2. WNT5A knockdown by siRNA decreases ROR2...

2022年1月31日 · Numerous essential roles of Wnt5a/Ror2 in development have been demonstrated. Therefore, Ror signaling pathway become a necessary target for diagnosing and treating human diseases. The Wnt5a- Ror2 signaling pathway as a critical factor has attracted extensive attention.

2023年12月20日 · In this study, we provide evidence that Wnt5b, together with Ror2, is loaded on long protrusions called cytonemes. Our data further suggest that the active Wnt5b–Ror2 complexes form in the producing cell and are handed over from these cytonemes to …

Ror2作为受体酪氨酸激酶家族中的成员之一,能够作为Wnt5a的受体或共受体参与调控Wnt5a诱导的非经典Wnt通路。 Wnt5a/Ror2在肿瘤细胞和具有侵袭性的肿瘤细胞中具有持续激活的能力,通过调节MMP-13的表达导致丝状伪足的形成,最终增强细胞的侵袭力。

WNT-5A activates ERK1/2 in intestinal epithelial cells via ROR2 [65], whereas it activates JNK-mediated c-Jun transcriptional activity to induce production of receptor activator of nuclear factor-κB (RANK), a regulator of osteoclast differentiation and activation, in …