Retinal Pigment Epithelial Cells Derived from Induced Pluripotent Stem ...
Human retinal pigment epithelial (RPE) cells derived from induced pluripotent stem (iPS) cells have immunosuppressive properties. However, RPE cells are also known as immunogenic …
Mechanism of Nucleic Acid Sensing in Retinal Pigment Epithelium (RPE …
2021年6月18日 · Our data demonstrate that RPE cells can respond to intracellular RNA and induce type I IFN responses via the RIG-I (DExD/H-box helicase 58, DDX58) RNA helicase. In …
Graft survival of major histocompatibility complex deficient stem …
2024年9月30日 · Here we show when MHC-II knockout RPE are transplanted into monkey eyes, they show suppressed immunogenicity with no infiltration of inflammatory cells, leading to …
Identification of cell surface markers and establishment of …
2020年3月30日 · In vitro differentiation of human pluripotent stem cells into functional retinal pigment epithelial (RPE) cells provides a potentially unlimited source for cell based reparative …
Detection of Retinal Pigment Epithelium-Specific Antibody in iPSC ...
2017年11月11日 · After RPE cell fixation, we determined whether antibodies present in the serum could detect RPE cells using IHC. The iPS-RPE cells (46a RPE cells or 1121A1 RPE cells) …
Retinal pigment epithelial integrity is compromised in the …
2016年12月12日 · In the developing murine eye, melanin synthesis in the retinal pigment epithelium (RPE) coincides with neurogenesis of retinal ganglion cells (RGCs). Disruption of …
Inducing human retinal pigment epithelium-like cells from somatic ...
2022年2月8日 · We stably induced RPE-like cells (iRPE) from human fibroblasts (Fibs) by conditional overexpression of both broad plasticity and lineage-specific transcription factors …
ADIPOR1 is essential for vision and its RPE expression is lost in the
2018年9月25日 · This analysis showed ADIPOR1 mRNA presence throughout the neural retina and the RPE. We then performed IHC on paraffin-embedded sections of human retinas to test …
c-Met Modulates RPE Migratory Response to Laser-Induced …
2012年7月13日 · Our findings indicate that constitutive activation of c-Met induced stronger RPE cell migration from the laser-induced injury site to outer layer of the retina; similarly, abrogation …
Expression and Distribution of β, β-Carotene ... - ARVO Journals
An EGFP-tagged BCO2 protein was expressed in human induced pluripotent stem cell-derived retinal pigment epithelium (iPSC-RPE) cells to further investigate BCO2’s subcellular …
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