2023年2月8日 · As an important ribosomal protein in the 40s subunit, RPS5, particularly its N-terminus, is intimately related to ribosomal translation, intracellular functions, and the development of liver diseases and cancers, implying that RPS5 could be a potential target for therapeutic intervention in liver diseases.

40S ribosomal protein S5 is a ribosomal subunit of the Eukaryotic ribosome (80S) complex. In humans it is encoded by the RPS5 gene. [5][6][7]

2024年12月25日 · Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 40S subunit.

Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is …

2023年2月8日 · This article focuses on the structure of RPS5 and its role in cells and diseases, especially the binding to 18S rRNA. The role of RPS5 in translation initiation and its potential use as targets for liver disease and cancer are discussed.

Eukaryotic Ribosomal Protein S5 of the 40S Subunit: Structure and Function. The ribosomal protein RPS5 is one of the prime proteins to combine with RNA and belongs to the conserved ribosomal protein family. It plays a substantial role in the process of translation and also has some non-ribosome functions.

One of the proteins that make up the small ribosomal subunit (called Rps5 in budding yeast) is located near the channel where the mRNA molecule exits the PIC during scanning, and is also thought to be involved in translation initiation. However, the role of Rps5 in recognizing the start codon is poorly understood.

ribosomal 40S subunit protein S5. Rps5 serine-223 phosphorylation is required for ribosomal small subunit maturation. Thus, remodeling of the uS7/eIF2alpha interface appears to stabilize first the open, and then the closed state of the eukaryotic pre-initiation complex to promote accurate AUG selection in vivo.

Eukaryotic Ribosomal Protein S5 of the 40S Subunit: Structure and Function. Stabilization of CDK6 by ribosomal protein uS7, a target protein of the natural product fucoxanthinol. Data indicate that beta hairpin structure present in ribosomal protein S5 (RPS5) is important for IRES-RPS5 interaction.

2024年10月28日 · Data indicate that beta hairpin structure present in ribosomal protein S5 (RPS5) is important for IRES-RPS5 interaction. Title: The beta hairpin structure within ribosomal protein S5 mediates interplay between domains II and IV and regulates HCV IRES function.