Ribonucleotide reductase M2 (RRM2) is a small subunit in ribonucleotide reductases, which participate in nucleotide metabolism and catalyze the conversion of nucleotides to deoxynucleotides, maintaining the dNTP pools for DNA biosynthesis, repair, and replication. RRM2 performs a critical role in the malignant biological behaviors of cancers.

Ribonucleoside-diphosphate reductase subunit M2, also known as ribonucleotide reductase small subunit, is an enzyme that in humans is encoded by the RRM2 gene. [5][6] This gene encodes one of two non-identical subunits for ribonucleotide reductase. This reductase catalyzes the formation of deoxyribonucleotides from ribonucleotides.

rrm2被认为是诊断、治疗和预后预测的一个有前途的靶标，对dna复制和癌细胞增殖至关重要。rrm2调控的分子机制极其复杂。例如，rrm2可以受某个途径调节，也可以调节该途径，形成反馈信号。在从转录到翻译的过程中，几乎每一个步骤都会发生调控。

2024年12月25日 · RRM2 (Ribonucleotide Reductase Regulatory Subunit M2) is a Protein Coding gene. Diseases associated with RRM2 include Diamond-Blackfan Anemia 20 and Choriocarcinoma. Among its related pathways are pyrimidine deoxyribonucleotides biosynthesis from CTP and purine nucleotides de novo biosynthesis.

Ribonucleotide reductase M2 (RRM2) is a small subunit in ribonucleotide reductases, which participate in nucleotide metabolism and catalyze the conversion of nucleotides to deoxynucleotides, maintaining the dNTP pools for DNA biosynthesis, repair, and replication. RRM2 performs a critical role in the malignant biological behaviors of cancers.

编码蛋白 (M2) 的合成以细胞周期依赖性方式进行调节。 该基因的转录可以从替代启动子开始，这会产生两种 N 末端长度不同的亚型。 已在 1 号和 X 号染色体上鉴定出相关的假基因。 [RefSeq 提供，2009 年 9 月] This gene encodes one of two non-identical subunits for ribonucleotide reductase. This reductase catalyzes the formation of deoxyribonucleotides from ribonucleotides.

[摘要] 目的 探讨核糖核苷酸还原酶调节亚基M2 (ribonucleotide reductase regulatory subunit M2，RRM2)在膀胱癌细胞中的生物学功能及其机制。 方法 采用TCGA及Oncomine数据库分析膀胱癌患者RRM2的表达，生存分析采用K-M Plot在线分析网站。...

2023年5月17日 · Comparing single-cell transcriptomic patterns identified distinct cellular populations present during TMZ therapy. Of interest was the increased expression of ribonucleotide reductase regulatory subunit M2 (RRM2), which we found to regulate dGTP and dCTP production vital for DNA damage response during TMZ therapy.

2024年1月1日 · Ribonucleotide reductase M2 (RRM2) is a small subunit in ribonucleotide reductases, which participate in nucleotide metabolism and catalyze the conversion of nucleotides to deoxynucleotides, maintaining the dNTP pools for DNA biosynthesis, repair, and replication. RRM2 performs a critical role in the malignant biological behaviors of cancers.

Ribonucleotide reductase subunit M2 (RRM2) is associated with the biological behaviours of cancers, including apoptosis, cell proliferation, invasion, cell cycle and migration. Previous studies have suggested that the expression of RRM2 plays …