The RSK family of kinases: emerging roles in cellular signalling
The 90 kDa ribosomal S6 kinase (RSK) family of proteins is a group of highly conserved Ser/Thr kinases that regulate diverse cellular processes, such as cell growth,...
Defining the role of the RSK isoforms in cancer - ScienceDirect
2018年2月1日 · Current limitations include the lack of RSK inhibitors with suitable pharmacokinetics and selectivity toward particular isoforms. This review briefly describes the …
Defining the role of the RSK isoforms in cancer - PubMed
The 90kDa ribosomal S6 kinase (RSK) family is a group of Ser/Thr protein kinases (RSK1-4) that function downstream of the Ras/mitogen-activated protein kinase (MAPK) signalling pathway. …
The p90 ribosomal S6 kinase (RSK) inhibitor BI-D1870 prevents
2013年10月17日 · The p90 ribosomal S6 kinase (RSK) inhibitor BI-D1870 prevents gamma irradiation-induced apoptosis and mediates senescence via RSK- and p53-independent …
The p90 RSK Family Members: Common Functions and Isoform …
2013年9月2日 · In cancer, RSKs modulate cell transformation, tumorigenesis, and metastasis. Indeed, changes in the expression of RSK isoforms have been reported in several …
Pp90RSK Isoforms Play Distinct Roles during Hematopoiesis
2020年11月5日 · Ribosomal S6 Kinases (RSKs) include a family of serine/threonine kinases that regulate cell proliferation and survival. In humans, four RSK isoforms (RSK1-4) have been …
Regulation and function of the RSK family of protein kinases
2012年1月15日 · The RSK (90 kDa ribosomal S6 kinase) family comprises a group of highly related serine/threonine kinases that regulate diverse cellular processes, including cell growth, …
Defining the role of the RSK isoforms in cancer - ScienceDirect
2018年2月1日 · As important downstream effectors of the Ras/MAPK pathway, the RSK isoforms represent attractive therapeutic targets for cancer [10], [11]. Herein, we will review and discuss …
The pp90rsk-CREB Signaling Pathway Regulates Apoptosis In …
2013年11月15日 · In summary, our data provide the first evidence that inhibition of CREB, or its chief activator RSK, is sufficient to induce apoptosis in AML cells. Current work focuses on …
Selective Targeting of RSK Isoforms in Cancer - ScienceDirect
2017年4月1日 · Current RSK inhibitors target more than one RSK isoform, and this may limit their efficacy as anticancer agents. Here, we review the structure and function of the RSK kinases, …