
The RSK family of kinases: emerging roles in cellular signalling
The 90 kDa ribosomal S6 kinase (RSK) family of proteins is a group of highly conserved Ser/Thr kinases that regulate diverse cellular processes, such as cell growth,...
Defining the role of the RSK isoforms in cancer - ScienceDirect
2018年2月1日 · Current limitations include the lack of RSK inhibitors with suitable pharmacokinetics and selectivity toward particular isoforms. This review briefly describes the current knowledge on RSK activation and function, with a particular emphasis on RSK-dependent mechanisms associated with tumorigenesis and pharmacological inhibition. Previous RSK ...
Defining the role of the RSK isoforms in cancer - PubMed
The 90kDa ribosomal S6 kinase (RSK) family is a group of Ser/Thr protein kinases (RSK1-4) that function downstream of the Ras/mitogen-activated protein kinase (MAPK) signalling pathway. RSK regulates many substrates involved in cell survival, growth, and proliferation, and as such, deregulated RSK a …
The p90 ribosomal S6 kinase (RSK) inhibitor BI-D1870 prevents
2013年10月17日 · The p90 ribosomal S6 kinase (RSK) inhibitor BI-D1870 prevents gamma irradiation-induced apoptosis and mediates senescence via RSK- and p53-independent accumulation of p21 WAF1/CIP1.
The p90 RSK Family Members: Common Functions and Isoform …
2013年9月2日 · In cancer, RSKs modulate cell transformation, tumorigenesis, and metastasis. Indeed, changes in the expression of RSK isoforms have been reported in several malignancies, including breast, prostate, and lung cancers. Four RSK isoforms have been identified in humans on the basis of their high degree of sequence homology.
Pp90RSK Isoforms Play Distinct Roles during Hematopoiesis
2020年11月5日 · Ribosomal S6 Kinases (RSKs) include a family of serine/threonine kinases that regulate cell proliferation and survival. In humans, four RSK isoforms (RSK1-4) have been identified. Although they are 73-80% conserved in sequence homology, RSK isoforms are reported to have distinct functions.
Regulation and function of the RSK family of protein kinases
2012年1月15日 · The RSK (90 kDa ribosomal S6 kinase) family comprises a group of highly related serine/threonine kinases that regulate diverse cellular processes, including cell growth, proliferation, survival and motility. This family includes four vertebrate isoforms (RSK1, RSK2, RSK3 and RSK4), and single family …
Defining the role of the RSK isoforms in cancer - ScienceDirect
2018年2月1日 · As important downstream effectors of the Ras/MAPK pathway, the RSK isoforms represent attractive therapeutic targets for cancer [10], [11]. Herein, we will review and discuss the potential roles of the RSK isoforms in cancer, as well as …
The pp90rsk-CREB Signaling Pathway Regulates Apoptosis In …
2013年11月15日 · In summary, our data provide the first evidence that inhibition of CREB, or its chief activator RSK, is sufficient to induce apoptosis in AML cells. Current work focuses on defining CREB target genes mediating XX-650-23 response using chromatin-immunoprecipitation with massively parallel DNA sequencing (ChIP-Seq), and defining the RSK kinome in ...
Selective Targeting of RSK Isoforms in Cancer - ScienceDirect
2017年4月1日 · Current RSK inhibitors target more than one RSK isoform, and this may limit their efficacy as anticancer agents. Here, we review the structure and function of the RSK kinases, their role in cancer growth and survival, and their potential as modulators of chemoresistance.