Understanding the differences between respiratory syncytial virus (RSV) subgroups A and B provides insights for the development of prevention strategies and public health interventions. We aimed to describe the structural differences of RSV …

RSV分为两个主要亚群，RSV A和RSV B，RSV A和RSV B亚群主要基于RSV G抗原和序列变异，RSV G是变异最大的RSV基因序列。 这两个亚群中的可以进一步区分和鉴定几种基因型。 尽管没有达成共识的基因型定义标准，但已描述了15种不同的RSV B基因型和9种不同的RSV A基因型。 呼吸道合胞病毒在全球范围内不断进化，多年来出现了新的基因型。 RSV B的基因型多样性大于RSV A，RSV A毒株可以分为9 种不同的基因型，但至少有37种RSV B基因型被报道。 这 …

The RSV F fusion glycoprotein in the prefusion conformation is a major target of virus neutralizing antibodies and differs in surface exposed regions between RSV A and RSV B. The subgroups co-circulate annually, but there is considerable debate as to whether clinical severity is impacted by the subgroup of the infecting RSV strain.

2022年8月16日 · RSV是与胰岛素样生长因子1（IGF1R）和蛋白激酶C zeta（PKCζ）结合，利用两者来产生信号，或者称“门铃”，将核仁素召唤到病毒所在的细胞表面。 一旦核仁素到达“指定”位置（门口），RSV就会与之结合，进入并感染细胞。

2019年8月28日 · Respiratory syncytial virus (RSV) is the main cause of hospitalization for bronchiolitis among infants. RSV is classified into two subtypes, A and B, whose predominance alternates during different epidemic seasons. The clinical impact of viral factors is controversial and many evidences suggest a critical role for the immune host response.

Respiratory syncytial virus (RSV) is the main cause of severe respiratory infections in young children. The need for global epidemiologic data regarding RSV has been increasingly recognized. RSV A infections are reported more frequently than RSV B. Nonetheless, the temporal distribution of infection …

2021年5月12日 · Human respiratory syncytial virus (HRSV) is the leading cause of bronchiolitis in infants. Two subgroups of HRSV (A and B) routinely cocirculate. Most research has been performed with HRSV-A strains because these are easier to culture than HRSV-B strains. In this study, we aimed to compare the repli …

2021年2月10日 · Respiratory syncytial virus (RSV) is a major cause of respiratory infections and is classified in two main groups, RSV-A and RSV-B, with multiple genotypes...

根据G蛋白抗原性不同，可将RSV分为A、B两个不同的亚型。 F蛋白可介导RSV病毒颗粒与宿主受体结合，帮助病毒颗粒进入宿主细胞，同时引起病毒感染细胞与周围细胞的融合从而形成合胞体。 F蛋白具有高度保守性，其诱导的抗体可同时对RSV A、B产生中和反应。 此外，F蛋白有融合前（pre-F）和融合后（post-F）两种构象，post-F构象相对稳定，但其诱导的抗体不能有效中和病毒的感染作用。 而亚稳定构象的pre-F有更多的中和表位，可诱导更高水平的中和抗体。 目 …

2014年8月30日 · To reconstruct the origin and phylodynamic history of RSV, we evaluated the genetic diversity and evolutionary dynamics of RSV A and RSV B isolated from children under 3 years old infected in Italy from 2006 to 2012.