2019年11月1日 · DNA/protein binding mode of ruthenium (II) complexes is high-lighted. In this review we summarize our work on development of Ru complexes with potential antitumor activity, which was performed over the last few years.

1990年6月1日 · What Are the Major Physicochemical Factors in Determining the Preferential Nuclear Uptake of the DNA “Light-Switching” Ru(II)-Polypyridyl Complex in Live Cells via Ion-Pairing with Chlorophenolate Counter-Anions?.

2021年8月11日 · This work presents the highest affinity mono-intercalating DNA binding complex to date, and represents the shortest linked Ru II (dppz) complex capable of DNA threading. Given the length of tpphz and the diameter of duplex DNA, any further reduction in the threading linker length could not be accommodated across the DNA helix (Figure 1 ).

2018年12月1日 · Ru complexes target various DNA conformations and affect DNA processing enzymes. DNA binding modes of Ru complexes of biological significance are highlighted. Ru complexes and light or ionizing radiation synergistically damage DNA. Ruthenium complexes exhibit a broad variety of biological and biomedical activities including anticancer efficiency.

2009年10月18日 · Here, we present a dinuclear ruthenium (II) polypyridyl system that works as a multifunctional biological imaging agent staining the DNA of eukaryotic and prokaryotic cells for both luminescence...

2016年8月25日 · Ruthenium (II) polypyridyl complexes can intercalate DNA with high affinity and prevent cell proliferation; however, the direct impact of ruthenium-based intercalation on cellular DNA...

2021年5月14日 · The dinuclear Ru (II) complex was found to display a distinctive blue-shifted ‘light-switch emission on its binding to G-quadruplex DNA compared with the duplex DNA (maxima of ~630 and >650...

2024年6月1日 · The photocleavage of plasmid pUC19 DNA was observed upon the irradiation of 1–3 with visible and red light, attributed to the sensitized generation of 1 O 2 by the complexes. These findings indicate that the bim ligand, together with pydppn, serves to shift the absorption of Ru(II) complexes to the photodynamic therapy window, 600–900 nm ...

2021年9月15日 · Ru(II)-polypyridyl complexes, binding to DNA, can cause DNA photodamage under irradiation. The AuNP-1-3 cellular uptake and localization can be tracked via confocal fluorescence microscopy. The NPs were localized in the cytoplasm and nuclei of cells [65].

[Ru(bpy)2dppz]2+和[Ru(phen)2dppz]2+作为脱氧核糖核酸(DNA)分子的光开关引起了广泛关注，成为探索DNA螺旋结构的有力工具. 由于钌化合物优异的光物理和光化学性质，它们的相互作用已被深入研究。