2024年8月1日 · To explore the transcriptional impact of Runx1 on metabolic pathways in colorectal cancer, we conducted bulk RNA-seq analysis on MC38 cells transfected with shNT and shRunx1. Our findings revealed significant alterations in gene expression, with 349 genes upregulated and 664 genes downregulated upon Runx1 knockdown ( Fig. 3 A).

2023年11月10日 · 活化的ahr结合转录因子runx1基因的启动子，促进runx1转录。 RUNX1随后影响MEP的其他基因表达，使MEP倾向分化为巨核细胞，导致血小板增多、红细胞减少。

2023年11月2日 · Here we show that tumor cell-released kynurenine (Kyn) biases megakaryocytic–erythroid progenitor cell (MEP) differentiation into megakaryocytes in individuals with cancer by activating the aryl...

Here we show that tumor cell-released kynurenine (Kyn) biases megakaryocytic–erythroid progenitor cell (MEP) diferentiation into megakaryocytes in individuals with cancer by activating the aryl...

该研究证明，地西他滨对Runx3的甲基化重编程在低剂量地西他滨和抗PD-1组合改善治疗反应中起关键作用，并且Runx3的表达水平是抗PD-1治疗反应的潜在生物标志物。 作者团队招募了两组接受抗PD-1治疗与抗PD-1/DAC（DP）治疗的患者。 从患者外周血中分离CD8+ T细胞，采用EPIC分析DNA甲基化，采用RNA-seq分析表达谱，并使用IPA和GSEA功能注释进行多组分析。 如图1所示，与抗PD-1治疗的患者相比，在DAC引发的抗PD-1治疗患者中检测到大规模去甲基化，并评 …

2024年5月22日 · Runt-related TF 1 (RUNX1), a member of the core-binding factor family of TFs, is involved in the regulation of a series of cellular processes, including cell growth, differentiation,...

2022年5月9日 · Our findings suggest that RUNX1 expression correlates with patient outcomes and immune infiltrate levels of CAFs in multiple tumors. Additionally, the increased level of RUNX1 was linked to the activation of oncogenic signaling pathways in human cancers, suggesting a potential role of RUNX1 among cancer therapeutic targets.

mc38异种移植模型的免疫学特性使其成为癌症研究的通用工具。 物种：小鼠，C57BL/6品系；雌性 组织：结肠；疾病：结肠腺癌

Cyp1a1 and Cyp1b1 expression in MEPs was determined by RT–qPCR (g), and MEPs were stained for RUNX1 (h). i, Ahr–/– mice were inoculated with MC38 cells, tumor-bearing mice were treated with ...

2023年5月16日 · We demonstrate that the DNA methylation of Runx3 plays a critical role in CD8+ T-cell infiltration and differentiation during decitabine-primed PD-1-ab immunotherapy, which provides a supporting mechanism for the essential role of epiregulation in immunotherapy.