2024年12月25日 · RAB27A (RAB27A, Member RAS Oncogene Family) is a Protein Coding gene. Diseases associated with RAB27A include Griscelli Syndrome, Type 2 and Griscelli Syndrome. Among its related pathways are MITF-M-dependent gene expression and Innate Immune System.

Ras-related protein Rab-27A is a protein that in humans is encoded by the RAB27A gene. [5][6] The protein encoded by this gene belongs to the small GTPase superfamily, Rab family. The protein is membrane-bound and may be involved in protein transport and small GTPase mediated signal transduction.

黑色素瘤细胞系中的rab27a缺乏在体外能够抑制三维球状体浸润和细胞迁移，并且在体内能够抑制自发性的肿瘤转移。 这种下降的浸润表型可被含有RAB27A的外泌体拯救，但不会被缺乏RAB27A的外泌体拯救，这表明RAB27A负责产生促进浸润的外泌体。

Rab27a 基因可通过其编码的蛋白参与 T 淋巴细胞、肥大细胞、嗜中性粒细胞、胰腺 β 细胞及造血细胞等的 颗粒分泌、运输及胞吐作用，参与白化病、癌症、糖尿病、炎症、血栓形成等疾病的发生发展。

2009年12月6日 · The small GTPases Rab27a and Rab27b and their effectors, Slp4 and Slac2b, control exosome secretion at different steps by regulating the peripheral localization, retention and docking of exosomal...

RAB27A，成员 RAS 致癌基因家族： 该基因编码的蛋白质属于小 GTPase 超家族 Rab 家族。 该蛋白质是膜结合的，可能参与蛋白质转运和小 GTP 酶介导的信号转导。

2021年2月25日 · Rab家族的成员之一Rab27a，当它沉默不发号施令时 （基因敲除） ，外秘体的分泌显著减少，而肿瘤转移也受到了阻碍 [4] 。值得注意的是，Rab27a的亲兄弟Rab7b在调节外泌体分泌的功能上大不相同。

The RAB27A gene provides instructions for making a protein that is involved in a process called vesicle trafficking, which moves proteins and other molecules within cells in sac-like structures called vesicles. Learn about this gene and related health conditions.

2024年12月10日 · Title: RAB27A promotes the proliferation and invasion of colorectal cancer cells. A Common variant in RAB27A gene is associated with fractional exhaled nitric oxide levels in adults.

该研究分别通过免疫荧光染色和交叉免疫沉淀（交叉IP）实验进一步证实KIBRA与Rab27a的共定位和结合。Rab27a通过与KIBRA相互作用而稳定，KIBRA通过泛素蛋白-蛋白酶体途径阻止Rab27a的泛素化和降解。

2023年4月8日 · RAB27a plays central role in the exosome secretion in triple-negative breast cancer cells, and inhibiting RAB27a can inhibit the proliferation, invasion and adhesion of the cells. Keywords: RAB27a, RAB27b, exosomes, triple …

Rab27A promotes cellular apoptosis and ROS production by regulating the miRNA-124-3p/STAT3/RelA signalling pathway in ulcerative colitis. Rab27a dependent exosome releasing participated in albumin handling as a coordinated approach to lysosome in kidney disease. RAB27A/Melanophilin Blocker Inhibits Melanoma Cell Motility and Invasion.

2020年7月8日 · Here we show that Rab27a expression was upregulated exclusively in tubular epithelial cells (TECs) during proteinuria nephropathy established by adriamycin (ADR) injection and 5/6 nephrectomy as...

2020年7月13日 · Here, the authors show that Rab27a coordinates SPIRE/FMN actin assembly and MyoVa motor proteins to generate a cell-wide actin/myosin network that links melanosomes and allows the collective ...

2022年11月12日 · RAB27A, the member of RAB27 family of small GTPases, is the critical protein for intracellular secretion and has been reported to promote tumor progression. However, it is controversial for the role of RAB27A in CRC progression, so we explored the exact function of RAB27A in CRC development in this study.

2025年2月17日 · We demonstrate that SYTL5-RAB27A positive vesicles containing mitochondrial material and LAMP1 form during hypoxia and that SYTL5 and RAB27A promote mitophagy under hypoxia mimicking conditions, indicating a role for these proteins in mitophagy.

2008年10月8日 · Rab GTPases coordinate vesicular trafficking within eukaryotic cells by collaborating with a set of effector proteins. Rab27a regulates numerous exocytotic pathways, and its dysfunction causes the Griscelli syndrome human immunodeficiency.

2022年11月12日 · RAB27A, the member of RAB27 family of small GTPases, is the critical protein for intracellular secretion and has been reported to promote tumor progression. However, it is controversial for the...

Using neutrophil-like differentiated HL60 cells, we show here that Rab27a plays an essential role in both phorbol myristate acetate (PMA)- and Candida albicans -induced NET formation by regulating ROS production. Rab27a-knockdown inhibited ROS-positive phagosome formation during complement-mediated phagocytosis.

2003年11月14日 · We found that Rab27a is expressed in an exceptionally broad range of specialized secretory cells, including exocrine (particularly in mucin- and zymogen-secreting cells), endocrine, ovarian, and hematopoietic cells, most of which undergo regulated exocytosis.