2024年12月25日 · RAB5A (RAB5A, Member RAS Oncogene Family) is a Protein Coding gene. Diseases associated with RAB5A include Lateral Sclerosis and Tuberculosis. Among its related pathways are Response of Mtb to phagocytosis and Infectious disease. Gene Ontology (GO) annotations related to this gene include GTP binding and GDP binding.

Ras-related protein Rab-5A is a protein that in humans is encoded by the RAB5A gene. [5][6] RAB5A localizes to early endosomes where it is involved in the recruitment of RAB7A and the maturation of these compartments to early endosomes. [7] .

Active GTP-bound form is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. RAB5A is required for the fusion of plasma membranes and early endosomes (PubMed:10818110, PubMed:14617813, PubMed:15378032, PubMed:16410077).

2020年2月12日 · By generating myogenic Rab5a-deficient mice, we uncover the essential roles of Rab5a in regulating skeletal muscle regeneration. We further reveal that Rab5a promotes myoblast differentiation...

Rab5a regulates fusion between pathogen-containing phagosomes and cytoplasmic organelles in human neutrophils an endocytotic catalyst, a tandem regulator of thyroid hormone production dynamin2 and Rab5 have roles in endocytosis of lysophosphatidic acid-coupled LPA1/EDG-2 …

1999年6月18日 · Rab5a is efficiently phosphorylated by extracellular-regulated kinase 1 but not by extracellular-regulated kinase 2, while cdc2 kinase preferentially phosphorylates Ser-123 of Rab5b. These findings strongly suggest that phosphorylation could be important to differentially regulate the function of the Rab5 isoforms.

rab5a，成员 ras 致癌基因家族： 启用 gdp 绑定活动； gtp 结合活性；和 gtpase 活性。 涉及多个过程，包括通过转胞吞作用清除淀粉样蛋白-β；早期内体到晚期内体的运输；和胞吐作用的调节。

RAB5A为RAB家族成员之一,主管囊泡融合和囊泡再循环.自1994年RAB5被发现以来,人们逐渐认识到RAB5在细胞物质运输中起重要作用.而于1999年以后,关于RAB5A的研究有大量报道,不但对其功能有了更深入的了解,而且对它的突变体和异构体均有一定的探讨.本文对RAB5A蛋白的结构、效应因子、功能和突变体等方面作一综述. 百度学术集成海量学术资源，融合人工智能、深度学习、大数据分析等技术，为科研工作者提供全面快捷的学术服务。 在这里我们保持学习的态度，不 …

摘要： 为研究rab5a基因在肿瘤转移机制中的作用，将该基因稳定转染至低转移肺腺癌细胞系AGZY83-a中，采用Superarray肿瘤转移相关基因微芯片分析rab5a对肿瘤转移相关基因的表达影响，共获得了5个差异表达基因，rab5a基因促进s100a4的表达，同时抑制了nm23a、rac1、cst3 ...

2004年1月15日 · RAB5A为RAB家族成员之一,主管囊泡融合和囊泡再循环.自1994年RAB5被发现以来,人们逐渐认识到RAB5在细胞物质运输中起重要作用.而于1999年以后,关于RAB5A的研究有大量报道,不但对其功能有了更深入的了解,而且对它的突变体和异构体均有一定的探讨.本文对RAB5A蛋白的结构、效应因子、功能和突变体等方面作一综述.

Ras-related protein (Rab-5a) is primarily involved in the regulation of early endosome fusion during endocytosis and takes part in the budding process. During GTP hydrolysis, Rab5a was spotted in the cytoplasmic side of early endosomes in association with the GTP.

2024年2月4日 · Title: Hepatitis B virus promotes its own replication by enhancing RAB5A-mediated dual activation of endosomal and autophagic vesicle pathways. Receptor-mediated internalization promotes increased endosome size and number in a RAB4- …

2003年5月15日 · RAB5A为RAB家族成员之一,主管囊泡融合和囊泡再循环.自1994年RAB5被发现以来,人们逐渐认识到RAB5在细胞物质运输中起重要作用.而于1999年以后,关于RAB5A的研究有大量报道,不但对其功能有了更深入的了解,而且对它的突变体和异构体均有一定的探讨.本文对RAB5A蛋白的结构、效应因子、功能和突变体等方面作一综述. Sorry, we did not find any related papers. What Is Semantic Scholar? Semantic Scholar is a free, AI-powered research tool for …

2021年11月5日 · Here we report on a positive correlation between the early endosome marker RAB5A and T-DM1 sensitivity in five HER2-positive cell lines.

Enables GTPase activity and guanyl nucleotide binding activity. Acts upstream of or within endocytosis. Located in several cellular components, including cytoplasmic vesicle; membrane raft; and ruffle. Is expressed in several structures, including brain; cardiovascular system; eye; genitourinary system; and gut.

2025年2月17日 · Rab5a played a critical role in the effect of ArfGAP3. (A) Comparison of relative mRNA expressions of Rab1, Rab5, Rab7, Rab11 and Rab34 in PFM of 3-, 8-, 12- and 24-month-old mice. (B) Correlation graphs between the mRNA and protein expression of ArfGAP3 and Rab5a in PFM of 3-, 8-, 12- and 24-month-old mice and in C2C12 myoblasts treated with D ...

2009年10月30日 · We investigated the activators/effectors of Rab5A that can potentially separate its potency in EGFR degradation from other isoforms and found that Rin1, a Rab5 exchange factor, preferably associated with Rab5A. Moreover, Rab5A activation is sensitive to EGF stimulation, and suppression of Rin1 diminished this sensitivity.

2009年12月18日 · Rab5a is currently a most interesting target because it is responsible for regulating the early endosome fusion in endocytosis and possibly the budding process. We utilized longtime-scale molecular dynamics simulations to investigate the internal motion of the wild-type Rab5a and its A30P mutant.

Rab5 has three isoforms (A, B, and C) sharing more than 90% of sequence identity. We individually ablated endogenous isoforms in HeLa cells with short interfering RNAs and examined the loss-of-function phenotypes. We found that suppression of Rab5A or 5B hampered the degradation of EGFR, whereas Rab5C depletion had very little effect.

Our data showed that Rab5a regulates C5aR1-mediated Akt phosphorylation but not ERK1/2 phosphorylation and calcium mobilization in M1-like HMDMs. These findings suggest that Rab5a effector proteins and compartmental signaling in endosomes are both likely involved in Akt phosphorylation.