A trimeric Rab7 GEF controls NPC1-dependent lysosomal ... - Nature
2020年11月3日 · We characterise C18orf8 as a core subunit of the mammalian Mon1-Ccz1 guanidine exchange factor (GEF) for Rab7, required for complex stability and function. …
A trimeric Rab7 GEF controls NPC1-dependent lysosomal cholesterol ...
2020年11月3日 · We characterise C18orf8 as a core subunit of the mammalian Mon1-Ccz1 guanidine exchange factor (GEF) for Rab7, required for complex stability and function. …
This Is the End: Regulation of Rab7 Nucleotide Binding in …
This review will discuss the GEF and GAPs that control Rab7 nucleotide binding, and thus regulate Rab7’s activity in endolysosomal trafficking and autophagy. It will also consider how …
Structure of the metazoan Rab7 GEF complex Mon1–Ccz1–Bulli
In metazoans, Rab7 controls endosomal maturation, autophagy, and lysosomal function. It is activated by the guanine nucleotide exchange factor (GEF) complex Mon1–Ccz1–Bulli …
RILP interacts with HOPS complex via VPS41 subunit to regulate ...
2014年12月2日 · In this study, we report that RILP, a downstream effector of Rab7, interacts with HOPS complex and recruits HOPS subunits to the late endosomal compartment. Structurally, …
Structure of the Mon1-Ccz1 complex reveals molecular basis of ... - PNAS
2022年2月1日 · The best-studied TLD Rab-GEF is MC1, which activates Rab7 (Ypt7 in yeast) in endosomal maturation and autophagy. In yeast, it has been demonstrated that MC1 …
【科技前沿】PNAS | 贾大/苏昭铭团队揭示高等生物中RAB7 …
2023年5月24日 · 在所有真核生物中，Mon1-Ccz1复合物一方面作为RAB7的GEF（鸟苷酸交换因子），可以促进RAB7从结合GDP的静息态向结合GTP的活化态转化；同时，Mon1-Ccz1作 …
A trimeric metazoan Rab7 GEF complex is crucial for ... - PubMed
2020年7月9日 · Recruitment of Rab7 to endosomes requires the Mon1-Ccz1 guanine-nucleotide-exchange factor (GEF). Here, we show that full function of the Drosophila Mon1-Ccz1 complex …
Rab regulation by GEFs and GAPs during membrane traffic
2019年8月1日 · Rab GTPases and their regulatory proteins play a crucial role in vesicle-mediated membrane trafficking. During vesicle membrane tethering Rab GTPases are activated by …
Rab GTPase Function in Endosome and Lysosome Biogenesis
2018年7月16日 · Rab GTPases are key factors that determine organelle identity throughout the endomembrane system. Endosomes change identity by replacing Rab5 with Rab7, which …