2024年12月25日 · RAB8A (RAB8A, Member RAS Oncogene Family) is a Protein Coding gene. Diseases associated with RAB8A include Microvillus Inclusion Disease and Open-Angle Glaucoma. Among its related pathways are Loss of proteins required for interphase microtubule organization from the centrosome and Rab regulation of trafficking.

Ras-related protein Rab-8A is a protein that in humans is encoded by the RAB8A gene. [5][6][7] The protein encoded by this gene is a member of the RAS superfamily which are small GTP/GDP-binding proteins with an average size of 200 amino acids.

2023年2月27日 · Here, we identify Rab8a as a mitochondrial receptor for LDs forming the tethering complex with the LD-associated PLIN5 in skeletal muscle. In rat L6 skeletal muscle cells, the energy sensor AMPK increases the GTP-bound active Rab8a that promotes LD-mitochondrion interaction through binding to PLIN5 upon starvation.

将线粒体纯化出来，WB检测Rab8a，发现线粒体中含有大量的Rab8a，而细胞质成分中则含有较少的Rab8a（上图c）。 将Rab8a点突变后（C204S)，Rab8a无法定位至线粒体（上图D）。

2024年11月15日 · Here, using biochemical and structural approaches, we systematically characterize the interaction between OPTN and Rab8a, revealing that OPTN selectively recognizes the GTP-bound active Rab8a through its leucine-zipper domain (LZD).

2023年2月23日 · 电镜分析和生化检测结果显示 Rab8a敲除显著降低了骨骼肌中脂滴与线粒体互作；进一步研究发现，Rab8a骨骼肌缺失小鼠在运动过程中脂肪酸利用率下降，其运动耐力显著受损。

2023年2月27日 · In this study, we identify Rab8a as a mitochondrial receptor for LDs in muscle cells via interacting with LD-associated PLIN5 upon AMPK activation, which regulates LCFA transfer from LDs into mitochondria for β-oxidation.

该蛋白与狗 RAB8、小鼠 MEL 和小鼠 YPT1 蛋白分别具有 97%、96% 和 51% 的相似性，并且包含存在于所有 Ras 蛋白中的 4 个 GTP/GDP 结合位点。 该蛋白质的推定效应结合位点与 RAB/YPT 蛋白质的相似。 然而，这种蛋白质包含一个 C 端 CAAX 基序，这是许多 Ras 超家族成员的特征，但在 YPT1 和大多数 RAB 蛋白中没有发现。 尽管该基因作为转化基因从黑色素瘤细胞系中分离出来，但尚未证明 MEL 与恶性黑色素瘤之间存在联系。 该致癌基因位于 19p13.1 染色体上 …

Rab8 is a multifunctional member of the small GTPase family of Rab molecular switches that commonly regulate membrane trafficking, cell shape, movement and receptor signalling [1, 2]. There are two isoforms of Rab8: Rab8a and 8b, which share 83% peptide sequence homology [3].

2013年11月13日 · The small GTP-binding protein Rab8 is known to play an essential role in intracellular transport and cilia formation. We have previously demonstrated that Rab8a is required for localising apical markers in various organisms. Rab8a has a closely related isoform, Rab8b. To determine whether Rab8b can …