Ran (RA s-related N uclear protein) also known as GTP-binding nuclear protein Ran is a protein that in humans is encoded by the RAN gene. Ran is a small 25 kDa protein that is involved in …

2016年1月10日 · In this mini-review we will describe briefly how the RanGTP system regulates the nucleo-cytoplasmic shuttling of components in interphase and, after NEBD, the activity …

2003年7月30日 · Here we demonstrate that RanGTP production is required to dissociate nucleoporins Nup107, Nup153 and Nup358 from Importin β, to target them to chromatin and to …

运输的能量主要由 细胞核 内与细胞质之间的RanGTP梯度提供。这种梯度的产生主要由于一种核内的蛋白——RanGEF，将Ran上的GDP交换为GTP，因此导致核内RanGTP浓度高于核外。

这是由小GTPaseRan调控的，它以GTP结合形式（RanGTP）结合Kapβ1，在细胞核内同时释放Kapα和NLS荷载。 NLS-NCs模拟真实的荷载特异性绕过NPCs进入细胞核。 它具有生物相容 …

2023年11月10日 · In this review, we will explore the structure, function, and disease relevance of individual NTPs, with a focus on their interaction mechanism and networks, underlying …

2008年5月15日 · RanGTP regulates the activity of NTRs to promote the recruitment of soluble cytoplasmic cargos to mitotic spindle structures by two different mechanisms that are not …

The cycling of Ran between its GTP- and GDP-bound forms is catalyzed by the chromatin-bound guanine nucleotide exchange factor RCC1 and the cytoplasmic Ran GTPase-activating protein …

2016年1月11日 · The identification and functional characterization of RanGTP mitotic targets is providing novel insights into mechanisms essential for cell division. Here we review our current …

2001年12月1日 · RanGTP in the nucleus binds to the importin and induces cargo release from the complex. The importin–RanGTP complex is then recycled to the cytoplasm, where RanGTP is …