
Rap1信号通路|G蛋白|信号通路-华美生物
Rap1,简称Ras相关蛋白1,是一种小G蛋白,属于Ras超家族。Rap1有两种异构体:Rap1A和Rap1B。与其他G蛋白一样,Rap1与GTP结合时具有活性,而与GDP结合时无活性。
Rap1 - Wikipedia
Rap1 (Ras-proximate-1 or Ras-related protein 1) is a small GTPase, which are small cytosolic proteins that act like cellular switches and are vital for effective signal transduction. [1] There are two isoforms of the Rap1 protein, each encoded by a separate gene, RAP1A and RAP1B .
rap1信号通路与炎症 - 华美生物
2023年3月28日 · Rap1(Ras-proximate-1)是一种小GTP酶,参与细胞内多种信号通路的调节。 Rap1信号通路参与了多种生物学过程,如细胞黏附、细胞极性、细胞增殖和细胞分化等,同时在炎症反应中也发挥了重要作用。
Rap1 signalling: adhering to new models - Nature
Rap1 is activated — that is increased GTP-bound over GDP-bound — by a large variety of extracellular stimuli through several evolutionarily conserved guanine nucleotide exchange factors (GEFs)...
Rap1 signaling pathway - Homo sapiens (human) - GenomeNet
Rap1 is a small GTPase that controls diverse processes, such as cell adhesion, cell-cell junction formation and cell polarity. Like all G proteins, Rap1 cycles between an inactive GDP-bound and an active GTP-bound conformation.
Rap1 signaling pathway - CUSABIO
Rap1, referred to as Ras-associated protein 1, is a small G protein that belongs to the Ras superfamily. Rap1 has two isoforms: Rap1A and Rap1B. Like other G proteins, Rap1 is active when bound to GTP but inactive when bound to GDP. What Is the Rap1 Signaling pathway?
Rap1的生物学功能与调控的研究进展 - 维普期刊官网
摘要 Rap1是小GTPases蛋白中Ras家族中的成员之一,最开始是在全基因组检测中作为Ras转化过程中的抑制因子被发现的。在功能上,Rap1既可以干扰Ras蛋白介导的ERK活化,也可以不依赖于Ras蛋白而以细胞环境相关的方...
Rap1 regulates hematopoietic stem cell survival and affects
2019年12月13日 · Herein using Rap1 null mice, we provide the genetic evidence that mammalian Rap1 plays a major role in hematopoietic stem cell survival, oncogenesis and response to chemotherapy.
rap1是血小板信号通路的主要汇聚点 - 华美生物
2023年5月8日 · RAP1(Ras-related protein 1)广泛存在于多种细胞中,并且在复杂的信号转导网络中扮演着重要的角色的小G蛋白。 在细胞外刺激作用下,RAP1被磷酸化,从而参与到各种生物学过程中,包括细胞增殖、分化、死亡、凋亡、黏附、迁移、肥大化等。
Rap1的生物学功能与调控的研究进展 - 百度学术
Rap1是小GTPases蛋白中Ras家族中的成员之一,最开始是在全基因组检测中作为Ras转化过程中的抑制因子被发现的.在功能上,Rap1既可以干扰Ras蛋白介导的ERK活化,也可以不依赖于Ras蛋白而以细胞环境相关的方式激活ERK.越来越多的证据证明,Rap1是整合素的一种主要激活因子 ...