Rap1，简称Ras相关蛋白1，是一种小G蛋白，属于Ras超家族。Rap1有两种异构体：Rap1A和Rap1B。与其他G蛋白一样，Rap1与GTP结合时具有活性，而与GDP结合时无活性。

Rap1 (Ras-proximate-1 or Ras-related protein 1) is a small GTPase, which are small cytosolic proteins that act like cellular switches and are vital for effective signal transduction. [1] There are two isoforms of the Rap1 protein, each encoded by a separate gene, RAP1A and RAP1B .

2023年3月28日 · Rap1（Ras-proximate-1）是一种小GTP酶，参与细胞内多种信号通路的调节。 Rap1信号通路参与了多种生物学过程，如细胞黏附、细胞极性、细胞增殖和细胞分化等，同时在炎症反应中也发挥了重要作用。

Rap1 is activated — that is increased GTP-bound over GDP-bound — by a large variety of extracellular stimuli through several evolutionarily conserved guanine nucleotide exchange factors (GEFs)...

Rap1 is a small GTPase that controls diverse processes, such as cell adhesion, cell-cell junction formation and cell polarity. Like all G proteins, Rap1 cycles between an inactive GDP-bound and an active GTP-bound conformation.

Rap1, referred to as Ras-associated protein 1, is a small G protein that belongs to the Ras superfamily. Rap1 has two isoforms: Rap1A and Rap1B. Like other G proteins, Rap1 is active when bound to GTP but inactive when bound to GDP. What Is the Rap1 Signaling pathway?

摘要 Rap1是小GTPases蛋白中Ras家族中的成员之一,最开始是在全基因组检测中作为Ras转化过程中的抑制因子被发现的。在功能上,Rap1既可以干扰Ras蛋白介导的ERK活化,也可以不依赖于Ras蛋白而以细胞环境相关的方...

2019年12月13日 · Herein using Rap1 null mice, we provide the genetic evidence that mammalian Rap1 plays a major role in hematopoietic stem cell survival, oncogenesis and response to chemotherapy.

2023年5月8日 · RAP1（Ras-related protein 1）广泛存在于多种细胞中，并且在复杂的信号转导网络中扮演着重要的角色的小G蛋白。 在细胞外刺激作用下，RAP1被磷酸化，从而参与到各种生物学过程中，包括细胞增殖、分化、死亡、凋亡、黏附、迁移、肥大化等。

Rap1是小GTPases蛋白中Ras家族中的成员之一,最开始是在全基因组检测中作为Ras转化过程中的抑制因子被发现的.在功能上,Rap1既可以干扰Ras蛋白介导的ERK活化,也可以不依赖于Ras蛋白而以细胞环境相关的方式激活ERK.越来越多的证据证明,Rap1是整合素的一种主要激活因子 ...