The MAPK/ERK pathway (also known as the Ras-Raf-MEK-ERK pathway) is a chain of proteins in the cell that communicates a signal from a receptor on the surface of the cell to the DNA in …

2020年6月23日 · RAS–ERK pathway activation stimulates pyrimidine synthesis by inducing MYC-dependent expression of pentose phosphate pathway (PPP) enzymes and by phosphorylating …

The Ras-extracellular signal-regulated kinase (Ras-ERK) and phosphatidylinositol 3-kinase-mammalian target of rapamycin (PI3K-mTOR) signaling pathways are the chief mechanisms …

The Ras/Raf/MAPK (MEK)/ERK pathway is the most important signalling cascade among all MAPK signal transduction pathways, and plays a crucial role in the survival and development …

One of the main signaling pathways downstream of RTKs and other cell surface receptors that is involved in stimulating many aspects of the cancer cell phenotype is the Extracellular …

The Raf-MEK-ERK pathway is commonly activated in human cancers, largely attributable to the extracellular signal-regulated kinases (ERKs) being a common downstream target of growth …

2025年3月7日 · Signaling Pathways: Ras activates downstream signaling molecules, such as Raf, MEK, and ERK, to control cell functions. The Ras protein is a crucial component of cellular …

2016年10月1日 · In this review, we discuss the signalling behaviour of RAS and RAF proteins in normal and in cancer cells, and the emerging systems-level properties of the RAS-to-ERK …

2025年3月4日 · In conclusion, the discovery that ARAF can form solid-like granules highlights a novel mechanism for modulating RAS–ERK signaling and fine-tune signaling outputs. …

2014年12月1日 · Sustained inhibition of ERK signalling in the tumour may be required for effective treatment of RAS/RAF mutant cancers. This may be achieved by combination strategies that …