另一个例子是，g12v和g12d突变均降低了对效应器raf的亲和力，但g12v会比g12d更好地激活raf，因为它更有效地降低了gtpase活性。 RAS信号强度的变化 RAS信号过多

2021年11月15日 · In addition, cells containing KRAS (G12C) or KRAS (G12V) have increased levels of RAS-related protein (RAL) A/B signalling and decreased levels of phosphorylation of …

kras g12a、 kras g12v GH55 是一款双机制ERK1/2抑制剂，它在抑制ERK1/2激酶活性的同时，能够抑制MEK对于ERK1/2的激活，防止由于负反馈调节造成的耐药。 体内外研究表明，GH55 …

KRAS G12V is a predictive biomarker for use of afatinib, dacomitinib, erlotinib, gefitinib, osimertinib, cetuximab, and panitumumab in patients. Of the therapies with KRAS G12V as a …

2023年10月12日 · Our study reveals the mechanisms of presentation and TCR recognition of KRAS-G12V mutant peptide and describes TCRs with therapeutic potency for tumor …

2024年9月19日 · 为了进一步探索在亚OIS条件下，不同剂量的致癌性RAS如何导致至少两种不同的肿瘤发生事件，研究人员分析了注射不同剂量NRAS (G12V) 的小鼠发展出的肿瘤，特别 …

5 天之前 · G12V Distinction in the RAS Family. The RAS family of small GTPases, including KRAS, NRAS, and HRAS, regulates cell proliferation, differentiation, and survival. While codon …

2025年3月13日 · Background Oncogenic KRAS mutations occur in nearly, 90% of patients with pancreatic ductal adenocarcinoma (PDAC). Targeting KRAS has been complicated by …

2025年3月8日 · The CypA:compound 1 binary complex exhibited weak binding affinity (K D2 assessed by surface plasmon resonance (SPR) assay) for KRAS G12V and this was sufficient …

5 天之前 · KRAS mutations occur frequently in pancreatic adenocarcinoma, with G12D, G12V, and G12R being the most frequent variants. Thus, knowledge gathered at molecular levels …