Targeting the K-Ras - JNK axis eliminates cancer stem-like cells …
Here we show that the K-Ras – JNK axis plays a pivotal role in the maintenance of pancreatic CSCs/CSLCs. In vitro inhibition of JNK, either pharmacological or genetic, caused loss of the …
胰腺癌细胞中的机械应力信号触发p38 MAPK和JNK依赖性细胞骨 …
K-Ras可以激活PI3K / AKT通路，但其主要靶点是MAPK信号级联反应，包括c-Jun N端激酶（JNK）和p38丝裂原活化蛋白激酶（p38 MAPK）。 在该团队以前的研究中，发现机械应力 …
Suppression of Ras-stimulated transformation by the JNK signal ...
The purpose of the present study was to examine the role of JNK in cell transformation by investigating the effect of targeted disruptions of the murine Jnk genes on Ras-stimulated …
PP6 Disruption Synergizes with Oncogenic Ras to Promote JNK …
2017年6月27日 · We identified fiery mountain (fmt), a regulatory subunit of the protein phosphatase 6 (PP6) complex, as a tumor suppressor that synergizes with RasV12 to drive c …
HMGB1 regulates erastin-induced ferroptosis via RAS-JNK…
The data suggest that HMGB1 is required for erastin-induced ferroptosis, the regulation of transferrin receptor protein 1 (TfR1) mRNA levels, and c-Jun N-terminal kinase (JNK) and p38 …
Blockade of Crk eliminates Yki/YAP-activated tumors via JNK
2024年9月28日 · We found that knockdown of Crk, the Drosophila ortholog of human CRK (CT10 regulatory kinase) and CRKL (Crk-like) adapter proteins, significantly suppresses growth of …
JNK信号通路 - 丁香园论坛 - DXY.cn
Rho 亚家族是小分子G蛋白Ras超家族（Ras见帖： Ras-Raf-MEK-ERK1/2信号通路 ）的成员之一。应激刺激（如紫外线、热休克、高渗刺激、蛋白合成抑制剂等)、细胞因子（TNF-α、IL-1) …
Inhibition of Ras/Raf/MEK/ERK Pathway Signaling by a Stress …
2016年12月1日 · Here, we identify a route for the phospho-inhibition of Ras/Raf/MEK/ERK pathway signaling that is mediated by the stress-activated JNK cascade. We find that key Ras …
JNK‐ and Fos‐regulated Mmp1 expression cooperates with Ras to …
2006年11月2日 · In cooperation with two oncogenic events, activated Ras and disrupted epithelial integrity, JNK enhances tumor malignancy via Fos‐dependent activation of the gene encoding …
Targeting the K-Ras--JNK axis eliminates cancer stem-like cells …
2014年7月15日 · Here we show that the K-Ras - JNK axis plays a pivotal role in the maintenance of pancreatic CSCs/CSLCs. In vitro inhibition of JNK, either pharmacological or genetic, …