KRAS (Kirsten rat sarcoma virus) is a gene that provides instructions for making a protein called K-Ras, a part of the RAS/MAPK pathway. The protein relays signals from outside the cell to the cell's nucleus.

The KRAS gene provides instructions for making a protein called K-Ras that is part of a signaling pathway known as the RAS/MAPK pathway. Learn about this gene and related health conditions.

The 3 primary RAS isoforms—KRAS, NRAS, and HRAS—are critical to cellular signaling, with KRAS mutations the most common and most frequently observed across the RAS family. KRAS mutations are particularly common in gastrointestinal (GI) malignancies, occurring in up to 40% to 50% of cases of colorectal cancer (CRC) and 90% of cases of ...

RAS mutations are changes in the RAS family of genes (KRAS, NRAS, and HRAS), which regulate cell growth and division. Mutations in RAS can cause cancer cells to grow uncontrollably, leading to cancer. RAS mutations are typically somatic mutations, meaning they occur in tumor cells during a person’s lifetime and are not passed down genetically.

2021年11月15日 · As the most frequently mutated oncogene, Kirsten rat sarcoma viral oncogene homologue (KRAS) has attracted substantial attention. The understanding of KRAS is constantly being updated by...

2024年4月18日 · Herein, we outline RAS pathobiology with a focus on KRAS, illustrate therapeutic approaches across a variety of malignancies, including emphasis on the ‘on’ and ‘off’ switch allele-specific and...

The KRAS protein is a GTPase that activates several signaling pathways involved in cancer survival. Although KRAS mutations have long been considered difficult to target, recent advances have led to the development of small-molecule inhibitors targeting the mutations, particularly KRAS G12C. These inhibitors are showing promise in GI cancers.

2025年1月15日 · The discovery of DNA encoding RAS guanosine triphosphatases in rat sarcoma viruses and the identification of oncogenic mutations in RAS genes in patients with cancer sparked a 50-year effort to...

GTPase KRas (KRAS) is a signal transducer protein, which plays an important role in various cellular signalling events such as in regulation of cell proliferation.

2024年11月9日 · Variants in the RAS family (HRAS, NRAS and KRAS) are among the most common mutations found in cancer. About 19% patients with cancer harbor RAS mutations, which are typically associated with poor clinical outcomes.