Ras drives malignancy through stem cell crosstalk with the ...
2022年11月30日 · Here we show in mice that, after oncogenic RAS activation, cancer stem cells rewire their gene expression program and trigger self-propelling, aberrant signalling crosstalk …
RAS-mediated suppression of PAR3 and its effects on SCC …
Here, using an inducible model of human squamous cell carcinoma (SCC), we demonstrate that RAS-dependent suppression of PAR3 (encoded by PARD3) accelerates epithelial …
Activation of the RAS/ERK signaling pathway by RASAL1 and its …
2020年9月1日 · To determine which RAS-GAPs are concerned with the activation of the RAS/ERK pathway in tongue SCC, we analyzed the relationship between mRNA levels of …
Raf-1 and Squamous Cell Carcinoma: Rok-ing the Boat - Cell Press
2009年8月4日 · To explore the function of Raf in Ras-driven SCC, the authors induced the ablation of Raf-1 in two mouse models: (1) the DMBA/TPA chemical carcinogenesis model in …
RASAL1激活RAS/ERK信号通路及其在舌鳞状细胞癌中的临床意义
受试者和方法 我们通过 PCR-单链构象多态性 (PCR-SSCP) 分析了 K-RAS、H-RAS 和 N-RAS 基因的突变，以及编码 RAS-GAP 的三个基因（RASAL1、NF1、和 DAB2IP) 通过实时逆转录 …
(PDF) Ras drives malignancy through stem cell crosstalk with the ...
2022年11月30日 · Squamous cell carcinomas are triggered by marked elevation of RAS–MAPK signalling and progression from benign papilloma to invasive malignancy1–4. At...
沉默Icmt基因对舌鳞癌CAL-27和SCC-4细胞增殖、凋亡及细胞周期 …
结论 体外沉默Icmt基因可有效抑制CAL-27和SCC-4细胞增殖且诱导凋亡,其作用可能是通过影响K-Ras膜蛋白靶向膜定位,负性调控细胞周期和下调Ras/PI3K/Akt/mTOR信号通路而实现。
Epidermal Growth Factor Receptor (EGFR)-RAS Signaling Pathway …
Penile Squamous Cell Carcinoma (SCC) is a rare cancer with poor prognosis and limited response to conventional chemotherapy. The genetic and epigenetic alterations of Epidermal …
Exploiting Mouse Models to Study Ras-Induced Cutaneous
2016年8月1日 · In this review, we will focus on experimental data gathered from murine models of Ras-initiated SCC where the consequence is known to be activation of this proto-oncogene. …
RASSF1A基因甲基化和SCC联合检测在非小细胞肺癌转移监测中的 …
Objective To explore the prognostic value of combined analysis of squamous cell carci-noma antigen (SCC)and DNA methylation of ras association domain family 1A (RASSF1A)in patients …