RNA-dependent RNA polymerase (RdRp) or RNA replicase is an enzyme that catalyzes the replication of RNA from an RNA template. Specifically, it catalyzes synthesis of the RNA strand complementary to a given RNA template.

2022年2月15日 · RdRps are considered as an outlier to the “central dogma” pathway in the initial molecular biology. RdRp, consisting of fingers, thumb and palm sub-domains, mainly performs the catalytic functions. RdRp inhibitors reported in the last few years have been analysed for design and binding mode.

RNA dependent RNA polymerase (RdRp) is one of the most versatile enzymes of RNA viruses that is indispensable for replicating the genome as well as for carrying out transcription. The core structural features of RdRps are conserved, despite the divergence in their sequences.

The RNA-dependent RNA polymerase (RdRp) is an essential enzyme for the viral replication process, catalyzing the viral RNA synthesis using a metal ion-dependent mechanism. In recent years, RdRp has emerged as an optimal target for the development of ...

2021年1月29日 · Remdesivir targets the RNA-dependent RNA polymerase (RdRp), an essential enzyme for viral RNA replication and a promising drug target for COVID-19. Recently, several structures of RdRp in complex with substrate RNA and remdesivir were reported, providing insights into the mechanisms of RNA recognition by RdRp.

2021年3月5日 · Within the RNA genome of infections is RNA-dependent RNA polymerase (RdRp), which is an essential enzyme that helps in RNA synthesis by catalysing the RNA template-dependent development of phosphodiester bonds.

2024年12月27日 · 🌐 What is the RdRp summit? The “RdRp Summit” is a discussion-centric event that aims to foster reproducibility, collaboration, and interoperability in omics-derived RNA virus discovery. The First RdRp Summit was held in Valencia, Spain, in 2023.

RNA-dependent RNA polymerases (RdRp) are very ancient enzymes and are essential for all viruses with RNA genomes. We reconstruct the origin and evolution of this polymerase since the initial stages of the origin of life. The origin of the RdRp was traced back from tRNA ancestors.